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dc.contributor.author
Sornette, Didier
dc.contributor.author
Favre, Maroussia
dc.date.accessioned
2019-04-17T12:41:37Z
dc.date.available
2017-06-11T22:05:18Z
dc.date.available
2019-04-17T12:41:37Z
dc.date.issued
2015-12-01
dc.identifier.issn
2195-0008
dc.identifier.other
10.1140/epjnbp/s40366-015-0026-0
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/108697
dc.identifier.doi
10.3929/ethz-b-000108697
dc.description.abstract
Tomasetti and Vogelstein recently proposed that the majority of variation in cancer risk among tissues is due to “bad luck,” that is, random mutations arising during DNA replication in normal noncancerous stem cells. They generalize this finding to cancer overall, claiming that “the stochastic effects of DNA replication appear to be the major contributor to cancer in humans.” We show that this conclusion results from a logical fallacy based on ignoring the influence of population heterogeneity in correlations exhibited at the level of the whole population. Because environmental and genetic factors cannot explain the huge differences in cancer rates between different organs, it is wrong to conclude that these factors play a minor role in cancer rates. In contrast, we show that one can indeed measure huge differences in cancer rates between different organs and, at the same time, observe a strong effect of environmental and genetic factors in cancer rates.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Cancer risk
en_US
dc.subject
Familial adenomatous polyposis
en_US
dc.subject
Lung cancer risk
en_US
dc.subject
Cancer rate
en_US
dc.subject
Huge difference
en_US
dc.title
Debunking mathematically the logical fallacy that cancer risk is just “bad luck”
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
EPJ Nonlinear Biomedical Physics
ethz.journal.volume
3
en_US
ethz.journal.abbreviated
EPJ nonlinear biomed. phys.
ethz.pages.start
10
en_US
ethz.size
6 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Heidelberg
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02120 - Dep. Management, Technologie und Ökon. / Dep. of Management, Technology, and Ec.::03738 - Sornette, Didier / Sornette, Didier
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02120 - Dep. Management, Technologie und Ökon. / Dep. of Management, Technology, and Ec.::03738 - Sornette, Didier / Sornette, Didier
ethz.date.deposited
2017-06-11T22:05:30Z
ethz.source
ECIT
ethz.identifier.importid
imp593653d3d5a2817809
ethz.ecitpid
pub:169706
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T07:26:05Z
ethz.rosetta.lastUpdated
2019-04-17T12:41:59Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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