Probabilistic modelling of prospective environmental concentrations of gold nanoparticles from medical applications as a basis for risk assessment

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Date
2015-12-22Type
- Journal Article
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Cited 47 times in
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Cited 49 times in
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Abstract
Background
The use of gold nanoparticles (Au-NP) based medical applications is rising due to their unique physical and chemical properties. Diagnostic devices based on Au-NP are already available in the market or are in clinical trials and Au-NP based therapeutics and theranostics (combined diagnostic and treatment modality) are in the research and development phase. Currently, no information on Au-NP consumption, material flows to and concentrations in the environment are available. Therefore, we estimated prospective maximal consumption of Au-NP from medical applications in the UK and US. We then modelled the Au-NP flows post-use and predicted their environmental concentrations. Furthermore, we assessed the environment risks of Au-NP by comparing the predicted environmental concentrations (PECs) with ecological threshold (PNEC) values.
Results
The mean annual estimated consumption of Au-NP from medical applications is 540 kg for the UK and 2700 kg for the US. Among the modelled concentrations of Au-NP in environmental compartments, the mean annual PEC of Au-NP in sludge for both the UK and US was estimated at 124 and 145 μg kg−1, respectively. The mean PEC in surface water was estimated at 468 and 4.7 pg L−1, respectively for the UK and US. The NOEC value for the water compartment ranged from 0.12 up to 26,800 μg L−1, with most values in the range of 1000 μg L−1.
Conclusion
The results using the current set of data indicate that the environmental risk from Au-NP used in nanomedicine in surface waters and from agricultural use of biosolids is minimal in the near future, especially because we have used a worst-case use assessment. More Au-NP toxicity studies are needed for the soil compartment. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000108877Publication status
publishedExternal links
Journal / series
Journal of NanobiotechnologyVolume
Pages / Article No.
Publisher
BioMed CentralSubject
Gold nanoparticles; Nanomedicine; Probabilistic modelling; Species sensitivity distribution; PEC; PNECOrganisational unit
03402 - Hungerbühler, Konrad (emeritus) / Hungerbühler, Konrad (emeritus)
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Citations
Cited 47 times in
Web of Science
Cited 49 times in
Scopus
ETH Bibliography
yes
Altmetrics