A control strategy for periodic systems - application to the twin-column MCSGP

Abstract

In this work we present advanced multi-parametric control strategies for the “Multicolumn Countercurrent Solvent Gradient Purification” (MCSGP) process, which is a continuous chromatographic separation process, governed by a periodic operation profile, linked to the intensification of monoclonal antibody production. We demonstrate a seamless, step-by-step procedure for the development of multi-parametric controllers as part of our recently introduced PAROC framework and software platform. The designed controller assures optimal operating conditions, avoiding pertubations, under continuous operation, while capturing the periodic nature of the process.