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dc.contributor.author
Katharios, Pantelis
dc.contributor.author
Seth-Smith, Helena M.B.
dc.contributor.author
Fehr, Alexander
dc.contributor.author
Mateos, José M.
dc.contributor.author
Qi, Weihong
dc.contributor.author
Richter, Denis
dc.contributor.author
Nufer, Lisbeth
dc.contributor.author
Ruetten, Maricruz
dc.contributor.author
Guevara Soto, Maricruz
dc.contributor.author
Ziegler, Urs
dc.contributor.author
Thomson, Nicholas R.
dc.contributor.author
Schlapbach, Ralph
dc.contributor.author
Vaughan, Lloyd
dc.date.accessioned
2018-10-23T14:47:41Z
dc.date.available
2017-06-11T23:19:12Z
dc.date.available
2018-10-23T14:47:41Z
dc.date.issued
2015-12-07
dc.identifier.other
10.1038/srep17609
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/110814
dc.identifier.doi
10.3929/ethz-b-000110814
dc.description.abstract
Aquaculture is a burgeoning industry, requiring diversification into new farmed species, which are often at risk from infectious disease. We used a mesocosm technique to investigate the susceptibility of sharpsnout seabream (Diplodus puntazzo) larvae to potential environmental pathogens in seawater compared to control borehole water. Fish exposed to seawater succumbed to epitheliocystis from 21 days post hatching, causing mortality in a quarter of the hosts. The pathogen responsible was not chlamydial, as is often found in epitheliocystis, but a novel species of the γ-proteobacterial genus Endozoicomonas. Detailed characterisation of this pathogen within the infectious lesions using high resolution fluorescent and electron microscopy showed densely packed rod shaped bacteria. A draft genome sequence of this uncultured bacterium was obtained from preserved material. Comparison with the genome of the Endozoicomonas elysicola type strain shows that the genome of Ca. Endozoicomonas cretensis is undergoing decay through loss of functional genes and insertion sequence expansion, often indicative of adaptation to a new niche or restriction to an alternative lifestyle. These results demonstrate the advantage of mesocosm studies for investigating the effect of environmental bacteria on susceptible hosts and provide an important insight into the genome dynamics of a novel fish pathogen.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Genome
en_US
dc.subject
Imaging
en_US
dc.subject
Water microbiology
en_US
dc.title
Environmental marine pathogen isolation using mesocosm culture of sharpsnout seabrea
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.title.subtitle
Striking genomic and morphological features of novel Endozoicomonas sp
en_US
ethz.journal.title
Scientific Reports
ethz.journal.volume
5
en_US
ethz.pages.start
17609
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.nebis
006751867
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung & Wirtschaftsbez. / Domain VP Research & Corporate Relations::02207 - Functional Genomics Center Zürich / Functional Genomics Center Zürich
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::08828 - Schlapbach, Ralph (Tit.-Prof.)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung & Wirtschaftsbez. / Domain VP Research & Corporate Relations::02207 - Functional Genomics Center Zürich / Functional Genomics Center Zürich
ethz.date.deposited
2017-06-11T23:19:54Z
ethz.source
ECIT
ethz.identifier.importid
imp593653fae885b79008
ethz.ecitpid
pub:172081
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T11:32:25Z
ethz.rosetta.lastUpdated
2019-01-02T14:54:26Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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