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dc.contributor.author
Koelle, Katia
dc.contributor.author
Rasmussen, David A.
dc.date.accessioned
2018-09-10T16:20:53Z
dc.date.available
2017-06-11T23:37:36Z
dc.date.available
2018-09-10T16:20:53Z
dc.date.issued
2015-09
dc.identifier.other
10.7554/eLife.07361
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/111475
dc.identifier.doi
10.3929/ethz-b-000111475
dc.description.abstract
Recent phylogenetic analyses indicate that RNA virus populations carry a significant deleterious mutation load. This mutation load has the potential to shape patterns of adaptive evolution via genetic linkage to beneficial mutations. Here, we examine the effect of deleterious mutations on patterns of influenza A subtype H3N2's antigenic evolution in humans. By first analyzing simple models of influenza that incorporate a mutation load, we show that deleterious mutations, as expected, act to slow the virus's rate of antigenic evolution, while making it more punctuated in nature. These models further predict three distinct molecular pathways by which antigenic cluster transitions occur, and we find phylogenetic patterns consistent with each of these pathways in influenza virus sequences. Simulations of a more complex phylodynamic model further indicate that antigenic mutations act in concert with deleterious mutations to reproduce influenza's spindly hemagglutinin phylogeny, co-circulation of antigenic variants, and high annual attack rates.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
The effects of a deleterious mutation load on patterns of influenza A/H3N2’s antigenic evolution in humans
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
eLife
ethz.journal.volume
4
en_US
ethz.pages.start
e07361
en_US
ethz.size
31 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.nebis
007613147
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09490 - Stadler, Tanja / Stadler, Tanja
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09490 - Stadler, Tanja / Stadler, Tanja
ethz.date.deposited
2017-06-11T23:38:24Z
ethz.source
ECIT
ethz.identifier.importid
imp593654060838056366
ethz.ecitpid
pub:172887
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-14T15:38:40Z
ethz.rosetta.lastUpdated
2018-09-10T16:20:59Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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