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dc.contributor.author
Gräff, Johannes
dc.contributor.author
Mansuy, Isabelle M.
dc.date.accessioned
2020-12-19T14:41:21Z
dc.date.available
2017-06-08T20:12:35Z
dc.date.available
2020-12-19T14:41:21Z
dc.date.issued
2008-09-01
dc.identifier.issn
0166-4328
dc.identifier.issn
1872-7549
dc.identifier.other
10.1016/j.bbr.2008.01.021
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/11298
dc.description.abstract
The epigenetic marking of chromatin provides a ubiquitous means for cells to shape and maintain their identity, and to react to environmental stimuli via specific remodeling. Such an epigenetic code of the core components of chromatin, DNA and histone proteins, can thus be stable but is also highly dynamic. In the nervous system, epigenetic codes are critical for basic cellular processes such as synaptic plasticity, and for complex behaviours such as learning and memory. At the same time, epigenetic marks can be stably transmitted through mitosis and meiosis, and thereby underlie non-genomic transgenerational inheritance of behavioural traits. In this review, we describe recent findings on the role and mechanisms of epigenetic codes in the brain, and discuss their implication in synaptic plasticity, cognitive functions and psychiatric disorders. We provide examples of transgenerational inheritance of epigenetic marks that affect simple morphological traits or complex processes such as disease susceptibility, and point to the potential implication of epigenetic codes in medicine and evolution.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Epigenetic mechanisms
en_US
dc.subject
Synaptic plasticity
en_US
dc.subject
Memory
en_US
dc.subject
DNA methylation
en_US
dc.subject
Histone
en_US
dc.subject
Cognition
en_US
dc.subject
Environment
en_US
dc.subject
Transgenerational inheritance
en_US
dc.title
Epigenetic codes in cognition and behaviour
en_US
dc.type
Journal Article
dc.date.published
2008-02-12
ethz.journal.title
Behavioural Brain Research
ethz.journal.volume
192
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Behav. brain res.
ethz.pages.start
70
en_US
ethz.pages.end
87
en_US
ethz.identifier.wos
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::03518 - Mansuy, Isabelle / Mansuy, Isabelle
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::03518 - Mansuy, Isabelle / Mansuy, Isabelle
ethz.date.deposited
2017-06-08T20:12:40Z
ethz.source
ECIT
ethz.identifier.importid
imp59364c00ee51627649
ethz.ecitpid
pub:22443
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-20T16:57:49Z
ethz.rosetta.lastUpdated
2022-03-29T04:37:22Z
ethz.rosetta.versionExported
true
ethz.COinS
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