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dc.contributor.author
Huys, Quentin J.M.
dc.contributor.author
Gölzer, Martin
dc.contributor.author
Friedel, Eva
dc.contributor.author
Heinz, Andreas
dc.contributor.author
Cools, Roshan
dc.contributor.author
Dayan, Peter
dc.contributor.author
Dolan, Raymond J.
dc.date.accessioned
2020-05-08T13:53:03Z
dc.date.available
2017-06-12T01:23:08Z
dc.date.available
2020-05-08T13:51:16Z
dc.date.available
2020-05-08T13:53:03Z
dc.date.issued
2016-04
dc.identifier.other
10.1017/S0033291715002597
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/113343
dc.identifier.doi
10.3929/ethz-b-000113343
dc.description.abstract
Background Changes in reflexive emotional responses are hallmarks of depression, but how emotional reflexes make an impact on adaptive decision-making in depression has not been examined formally. Using a Pavlovian-instrumental transfer (PIT) task, we compared the influence of affectively valenced stimuli on decision-making in depression and generalized anxiety disorder compared with healthy controls; and related this to the longitudinal course of the illness. Method A total of 40 subjects with a current DSM-IV-TR diagnosis of major depressive disorder, dysthymia, generalized anxiety disorder, or a combination thereof, and 40 matched healthy controls performed a PIT task that assesses how instrumental approach and withdrawal behaviours are influenced by appetitive and aversive Pavlovian conditioned stimuli (CSs). Patients were followed up after 4–6 months. Analyses focused on patients with depression alone (n = 25). Results In healthy controls, Pavlovian CSs exerted action-specific effects, with appetitive CSs boosting active approach and aversive CSs active withdrawal. This action-specificity was absent in currently depressed subjects. Greater action-specificity in patients was associated with better recovery over the follow-up period. Conclusions Depression is associated with an abnormal influence of emotional reactions on decision-making in a way that may predict recovery.
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dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cambridge University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Decision-making
en_US
dc.subject
Emotional reactions
en_US
dc.subject
Major depressive disorder
en_US
dc.subject
Pavlovian-instrumental transfer
en_US
dc.title
The specificity of Pavlovian regulation is associated with recovery from depression
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Psychological Medicine
ethz.journal.volume
46
en_US
ethz.journal.issue
5
en_US
ethz.pages.start
1027
en_US
ethz.pages.end
1035
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.date.deposited
2017-06-12T01:23:11Z
ethz.source
ECIT
ethz.identifier.importid
imp59365425c36bb71902
ethz.ecitpid
pub:175034
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T12:22:28Z
ethz.rosetta.lastUpdated
2021-02-15T10:56:06Z
ethz.rosetta.versionExported
true
ethz.COinS
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