The interdependence of transcript and protein abundance: New data-new complexities

Open access
Author
Liu, Yansheng
Aebersold, Ruedi
Date
2016-01Type
- Other Journal Item
Abstract
The relative contribution of transcriptional and translational regulation in gene expression control has been intensely debated and remains a challenging question. Recent reports have suggested that protein abundance in mammalian cells is primarily controlled at the transcript‐level. In their recent work, Cheng et al (2016) determined the proteomic and transcriptomic changes in cells responding to endoplasmic reticulum (ER) stress. Their analyses indicate that the ER stress response is significantly controlled at both the transcript and protein levels Show more
Permanent link
https://doi.org/10.3929/ethz-b-000113370Publication status
publishedJournal / series
Molecular Systems BiologyVolume
Pages / Article No.
Publisher
Nature Publ. GroupOrganisational unit
03663 - Aebersold, Rudolf / Aebersold, Rudolf
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