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dc.contributor.author
Vonesch, Sibylle C.
dc.contributor.author
Lamparter, David
dc.contributor.author
Mackay, Trudy F.C.
dc.contributor.author
Bergmann, Sven
dc.contributor.author
Hafen, Ernst
dc.date.accessioned
2018-10-25T14:01:43Z
dc.date.available
2017-06-12T01:41:00Z
dc.date.available
2018-10-25T14:01:43Z
dc.date.issued
2016-01-11
dc.identifier.issn
1553-7390
dc.identifier.issn
1553-7404
dc.identifier.other
10.1371/journal.pgen.1005616
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/113522
dc.identifier.doi
10.3929/ethz-b-000113522
dc.description.abstract
Organismal size depends on the interplay between genetic and environmental factors. Genome-wide association (GWA) analyses in humans have implied many genes in the control of height but suffer from the inability to control the environment. Genetic analyses in Drosophila have identified conserved signaling pathways controlling size; however, how these pathways control phenotypic diversity is unclear. We performed GWA of size traits using the Drosophila Genetic Reference Panel of inbred, sequenced lines. We find that the top associated variants differ between traits and sexes; do not map to canonical growth pathway genes, but can be linked to these by epistasis analysis; and are enriched for genes and putative enhancers. Performing GWA on well-studied developmental traits under controlled conditions expands our understanding of developmental processes underlying phenotypic diversity.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science (PLoS)
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS Genetics
ethz.journal.volume
12
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
PLoS Genet
ethz.pages.start
e1005616
en_US
ethz.size
29 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Genetic Dissection of Growth and Size Control in the Model Organism Drosophila
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
005410305
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03710 - Hafen, Ernst / Hafen, Ernst
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03710 - Hafen, Ernst / Hafen, Ernst
ethz.grant.agreementno
135699
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Bonus of Excellence
ethz.date.deposited
2017-06-12T01:42:32Z
ethz.source
ECIT
ethz.identifier.importid
imp593654295038931270
ethz.ecitpid
pub:175218
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T12:24:32Z
ethz.rosetta.lastUpdated
2018-10-25T14:01:52Z
ethz.rosetta.versionExported
true
ethz.COinS
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