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dc.contributor.author
Imbach, Lukas L.
dc.contributor.author
Baumann-Vogel, Heide
dc.contributor.author
Baumann, Christian R.
dc.contributor.author
Sürücü, Oguzkan
dc.contributor.author
Hermsdörfer, Joachim
dc.contributor.author
Sarnthein, Johannes
dc.date.accessioned
2019-07-01T11:22:26Z
dc.date.available
2017-06-12T04:22:20Z
dc.date.available
2019-07-01T11:22:26Z
dc.date.issued
2015
dc.identifier.issn
2213-1582
dc.identifier.other
10.1016/j.nicl.2015.09.010
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/115275
dc.identifier.doi
10.3929/ethz-b-000115275
dc.description.abstract
Introduction Healthy subjects scale grip force to match the load defined by physical object properties such as weight, or dynamic properties such as inertia. Patients with Parkinson's disease (PD) show an elevated grip force in dynamic object handling, but temporal aspects of anticipatory grip force control are relatively preserved. In PD patients, beta frequency oscillatory activity in the basal ganglia is suppressed prior to externally paced movements. However, the role of the subthalamic nucleus (STN) in anticipatory grip force control is not known. Methods After implantation of deep brain stimulation (DBS) electrodes in the STN, PD patients performed adaptive and voluntary grip force tasks, while we recorded subthalamic local field potentials (LFP) and scalp EEG. Results During adaptive grip force control (Shake), we found event related desynchronization (ERD) in the beta frequency band, which was time-locked to the grip force. In contrast, during voluntary grip force control (Press) we recorded a biphasic ERD, corresponding to peak grip force and grip force release. Beta synchronization between STN and cortical EEG was reduced during adaptive grip force control. Conclusion The time-locked suppression of beta oscillatory activity in the STN is in line with previous reports of beta ERD prior to voluntary movements. Our results show that the STN is involved in anticipatory grip force control in PD patients. The difference in the phasic beta ERD between the two tasks and the reduction of cortico-subthalamic synchronization suggests that qualitatively different neuronal network states are involved in different grip force control tasks.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Subthalamic nucleus
en_US
dc.subject
Motor control
en_US
dc.subject
EEG
en_US
dc.subject
Synchronization
en_US
dc.subject
Beta oscillations
en_US
dc.title
Adaptive grip force is modulated by subthalamic beta activity in Parkinson's disease patients
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2015-09-29
ethz.journal.title
NeuroImage: Clinical
ethz.journal.volume
9
en_US
ethz.pages.start
450
en_US
ethz.pages.end
457
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007621316
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-12T04:26:09Z
ethz.source
ECIT
ethz.identifier.importid
imp593654503367863962
ethz.ecitpid
pub:177100
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T10:47:43Z
ethz.rosetta.lastUpdated
2019-07-01T11:22:35Z
ethz.rosetta.versionExported
true
ethz.COinS
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