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dc.contributor.author
Petrinovic, Marija M.
dc.contributor.author
Hankov, Georges
dc.contributor.author
Schroeter, Aileen
dc.contributor.author
Bruns, Andreas
dc.contributor.author
Rudin, Markus
dc.contributor.author
von Kienlin, Markus
dc.contributor.author
Künnecke, Basil
dc.contributor.author
Mueggler, Thomas
dc.date.accessioned
2018-09-13T14:53:44Z
dc.date.available
2017-06-12T05:08:22Z
dc.date.available
2018-09-13T14:53:44Z
dc.date.issued
2016-04-15
dc.identifier.other
10.1038/srep24523
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/115835
dc.identifier.doi
10.3929/ethz-b-000115835
dc.description.abstract
Functional magnetic resonance imaging (fMRI) has revolutionized neuroscience by opening a unique window that allows neurocircuitry function and pathological alterations to be probed non-invasively across brain disorders. Here we report a novel sustainable anesthesia procedure for small animal neuroimaging that overcomes shortcomings of anesthetics commonly used in rodent fMRI. The significantly improved preservation of cerebrovascular dynamics enhances sensitivity to neural activity changes for which it serves as a proxy in fMRI readouts. Excellent cross-species/strain applicability provides coherence among preclinical findings and is expected to improve translation to clinical fMRI investigations. The novel anesthesia procedure based on the GABAergic anesthetic etomidate was extensively validated in fMRI studies conducted in a range of genetically engineered rodent models of autism and strains commonly used for transgenic manipulations. Etomidate proved effective, yielded long-term stable physiology with basal cerebral blood flow of ~0.5 ml/g/min and full recovery. Cerebrovascular responsiveness of up to 180% was maintained as demonstrated with perfusion- and BOLD-based fMRI upon hypercapnic, pharmacological and sensory stimulation. Hence, etomidate lends itself as an anesthetic-of-choice for translational neuroimaging studies across rodent models of brain disorders.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Neuro–vascular interactions
en_US
dc.subject
Autism spectrum disorders
en_US
dc.title
A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Scientific Reports
ethz.journal.volume
6
en_US
ethz.pages.start
24523
en_US
ethz.size
12 p
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
006751867
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03750 - Rudin, Markus (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03750 - Rudin, Markus (emeritus)
ethz.date.deposited
2017-06-12T05:15:17Z
ethz.source
ECIT
ethz.identifier.importid
imp5936545acb09e54284
ethz.ecitpid
pub:177672
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T18:46:01Z
ethz.rosetta.lastUpdated
2019-01-02T14:00:38Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=A%20novel%20anesthesia%20regime%20enables%20neurofunctional%20studies%20and%20imaging%20genetics%20across%20mouse%20strains&rft.jtitle=Scientific%20Reports&rft.date=2016-04-15&rft.volume=6&rft.spage=24523&rft.au=Petrinovic,%20Marija%20M.&Hankov,%20Georges&Schroeter,%20Aileen&Bruns,%20Andreas&Rudin,%20Markus&rft.genre=article&
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