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dc.contributor.author
Mansouri, Abdelhak
dc.contributor.author
Koss, Michael D.
dc.contributor.author
Brandt, Karsten
dc.contributor.author
Geary, Nori
dc.contributor.author
Langhans, Wolfgang
dc.contributor.author
Leonhardt, Monika
dc.date.accessioned
2021-03-24T09:25:29Z
dc.date.available
2017-06-08T20:19:55Z
dc.date.available
2021-03-24T09:25:29Z
dc.date.issued
2008-04
dc.identifier.issn
0899-9007
dc.identifier.issn
1873-1244
dc.identifier.other
10.1016/j.nut.2007.12.008
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/11651
dc.description.abstract
Objective and Methods Mercaptoacetate (MA) inhibits hepatic fatty acid oxidation (FAO) and stimulates feeding in rats fed fat-rich diets. To test whether the feeding stimulation by MA depends on hepatic FAO, we compared the effects of intraperitoneally injected MA (45.6 mg/kg body weight) with saline in rats fed diets containing 18% predominately long-chain triacylglycerols (LCTs; ≥90% 16 C) or 18% medium-chain triacylglycerols (MCTs; 51% 10–12 C). We hypothesized that, because medium-chain fatty acids reach the liver and are oxidized faster than long-chain fatty acids, if MA’s feeding-stimulatory effect depends on hepatic FAO, MA should stimulate feeding more in MCT-fed rats than in LCT-fed rats. Results Although MA injected in mid-light phase stimulated feeding similarly in MCT- and LCT-fed rats, MA injected at light onset initially stimulated food intake (1 h) only in LCT- and not in MCT-fed rats. To investigate MA’s metabolic effects during the initial hour, rats were sacrificed 30 min after light-onset injections. At this time plasma β-hydroxybutyrate appeared to be higher in MCT- than in LCT-fed rats and to be increased by MA. In a final experiment, MA did not affect fatty acid content in liver and duodenum tissues but increased fatty acids in duodenal tissue mitochondria from 12 h-fasted rats fed chow. Conclusion In light-onset tests, adaptation to the MCT diet increased hepatic FAO but not the feeding-stimulatory effect of MA in comparison with adaptation to the LCT diet, suggesting that at this time MA does not act in the liver to stimulate feeding or that this effect is not due to FAO inhibition. Inhibition of duodenal mitochondrial FAO may be another metabolic process through which MA stimulates feeding.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Food intake
en_US
dc.subject
Hepatic fatty acid oxidation
en_US
dc.subject
Fatty acid chain length
en_US
dc.subject
Ketone bodies
en_US
dc.title
Dissociation of mercaptoacetate's effects on feeding and fat metabolism by dietary medium- and long-chain triacylglycerols in rats
en_US
dc.type
Journal Article
dc.date.published
2008-01-30
ethz.journal.title
Nutrition
ethz.journal.volume
24
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Nutr
ethz.pages.start
360
en_US
ethz.pages.end
365
en_US
ethz.identifier.wos
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03274 - Langhans, Wolfgang (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03274 - Langhans, Wolfgang (emeritus)
ethz.date.deposited
2017-06-08T20:20:04Z
ethz.source
ECIT
ethz.identifier.importid
imp59364c081ee8441989
ethz.ecitpid
pub:22854
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-19T09:41:45Z
ethz.rosetta.lastUpdated
2022-03-29T05:57:17Z
ethz.rosetta.versionExported
true
ethz.COinS
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