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dc.contributor.author
Chen, Jerry L.
dc.contributor.author
Voigt, Fabian F.
dc.contributor.author
Javadzadeh, Mitra
dc.contributor.author
Krueppel, Roland
dc.contributor.author
Helmchen, Fritjof
dc.date.accessioned
2018-09-11T12:11:49Z
dc.date.available
2017-06-12T07:59:59Z
dc.date.available
2018-09-11T12:11:49Z
dc.date.issued
2016-05
dc.identifier.issn
2050-084X
dc.identifier.other
10.7554/eLife.14679
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/117679
dc.identifier.doi
10.3929/ethz-b-000117679
dc.description.abstract
The coordination of activity across neocortical areas is essential for mammalian brain function. Understanding this process requires simultaneous functional measurements across the cortex. In order to dissociate direct cortico-cortical interactions from other sources of neuronal correlations, it is furthermore desirable to target cross-areal recordings to neuronal subpopulations that anatomically project between areas. Here, we combined anatomical tracers with a novel multi-area two-photon microscope to perform simultaneous calcium imaging across mouse primary (S1) and secondary (S2) somatosensory whisker cortex during texture discrimination behavior, specifically identifying feedforward and feedback neurons. We find that coordination of S1-S2 activity increases during motor behaviors such as goal-directed whisking and licking. This effect was not specific to identified feedforward and feedback neurons. However, these mutually projecting neurons especially participated in inter-areal coordination when motor behavior was paired with whisker-texture touches, suggesting that direct S1-S2 interactions are sensory-dependent. Our results demonstrate specific functional coordination of anatomically-identified projection neurons across sensory cortices.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Long-range population dynamics of anatomically defined neocortical networks
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
eLife
ethz.journal.volume
5
en_US
ethz.pages.start
e14679
en_US
ethz.size
26 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
007613147
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-12T08:02:40Z
ethz.source
ECIT
ethz.identifier.importid
imp5936547dc0d4048256
ethz.ecitpid
pub:179596
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-17T08:25:14Z
ethz.rosetta.lastUpdated
2022-03-28T21:14:05Z
ethz.rosetta.versionExported
true
ethz.COinS
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