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dc.contributor.author
Vandenberg, Laura N.
dc.contributor.author
Ågerstrand, Marlene
dc.contributor.author
Beronius, Anna
dc.contributor.author
Beausoleil, Claire
dc.contributor.author
Bergman, Åke
dc.contributor.author
Bero, Lisa A.
dc.contributor.author
Bornehag, Carl-Gustav
dc.contributor.author
Boyer, C. Scott
dc.contributor.author
Cooper, Glinda S.
dc.contributor.author
Cotgreave, Ian
dc.contributor.author
Gee, David
dc.contributor.author
Grandjean, Philippe
dc.contributor.author
Guyton, Kathryn Z.
dc.contributor.author
Hass, Ulla
dc.contributor.author
Heindel, Jerrold J.
dc.contributor.author
Jobling, Susan
dc.contributor.author
Kidd, Karen A.
dc.contributor.author
Kortenkamp, Andreas
dc.contributor.author
Macleod, Malcolm R.
dc.contributor.author
Martin, Olwenn V.
dc.contributor.author
Norinder, Ulf
dc.contributor.author
Scheringer, Martin
dc.contributor.author
Thayer, Kristina A.
dc.contributor.author
Toppari, Jorma
dc.contributor.author
Whaley, Paul
dc.contributor.author
Woodruff, Tracey J.
dc.contributor.author
Rudén, Christina
dc.date.accessioned
2019-06-28T13:49:14Z
dc.date.available
2017-06-12T09:59:28Z
dc.date.available
2019-06-28T13:49:14Z
dc.date.issued
2016-07-14
dc.identifier.issn
1476-069X
dc.identifier.other
10.1186/s12940-016-0156-6
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/118912
dc.identifier.doi
10.3929/ethz-b-000118912
dc.description.abstract
Background The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs. Methods We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity. Results Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs. Conclusions When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Adverse effect
en_US
dc.subject
Endocrine disrupting activity
en_US
dc.subject
Endocrine disrupting chemicals
en_US
dc.subject
Epidemiology
en_US
dc.subject
Evidence integration
en_US
dc.subject
In vivo
en_US
dc.subject
Strength of evidence
en_US
dc.subject
Study evaluation
en_US
dc.subject
Systematic review
en_US
dc.subject
Weight of evidence
en_US
dc.title
A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Environmental Health
ethz.journal.volume
15
en_US
ethz.journal.abbreviated
Environ. Health
ethz.pages.start
74
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
004715998
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03402 - Hungerbühler, Konrad (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03402 - Hungerbühler, Konrad (emeritus)
ethz.date.deposited
2017-06-12T10:07:23Z
ethz.source
ECIT
ethz.identifier.importid
imp593654966805e98820
ethz.ecitpid
pub:180898
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T00:48:51Z
ethz.rosetta.lastUpdated
2019-06-28T13:49:23Z
ethz.rosetta.versionExported
true
ethz.COinS
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