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dc.contributor.author
Barribeau, Seth M.
dc.contributor.author
Schmid-Hempel, Paul
dc.contributor.author
Sadd, Ben M.
dc.date.accessioned
2018-08-09T07:24:16Z
dc.date.available
2017-06-12T10:02:08Z
dc.date.available
2018-08-09T07:24:16Z
dc.date.issued
2016-07-21
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0159635
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/118944
dc.identifier.doi
10.3929/ethz-b-000118944
dc.description.abstract
Invertebrates lack the cellular and physiological machinery of the adaptive immune system, but show specificity in their immune response and immune priming. Functionally, immune priming is comparable to immune memory in vertebrates. Individuals that have survived exposure to a given parasite are better protected against subsequent exposures. Protection may be cross-reactive, but demonstrations of persistent and specific protection in invertebrates are increasing. This immune priming can cross generations ("trans-generational" immune priming), preparing offspring for the prevailing parasite environment. While these phenomena gain increasing support, the mechanistic foundations underlying such immune priming, both within and across generations, remain largely unknown. Using a transcriptomic approach, we show that exposing bumblebee queens with an injection of heat-killed bacteria, known to induce trans-generational immune priming, alters daughter (worker) gene expression. Daughters, even when unexposed themselves, constitutively express a core set of the genes induced upon direct bacterial exposure, including high expression of antimicrobial peptides, a beta-glucan receptor protein implicated in bacterial recognition and the induction of the toll signaling pathway, and slit-3 which is important in honeybee immunity. Maternal exposure results in a distinct upregulation of their daughters’ immune system, with a signature overlapping with the induced individual response to a direct exposure. This will mediate mother-offspring protection, but also associated costs related to reconfiguration of constitutive immune expression. Moreover, identification of conserved immune pathways in memory-like responses has important implications for our understanding of the innate immune system, including the innate components in vertebrates, which share many of these pathways.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/publicdomain/zero/1.0/
dc.title
Royal Decree: Gene Expression in Trans-Generationally Immune Primed Bumblebee Workers Mimics a Primary Immune Response
en_US
dc.type
Journal Article
dc.rights.license
CC0 1.0 Universal
ethz.journal.title
PLoS ONE
ethz.journal.volume
11
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0159635
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Resistance systems and population structure of parasites
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
006206116
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.grant.agreementno
268853
ethz.grant.fundername
EC
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.program
FP7
ethz.date.deposited
2017-06-12T10:07:23Z
ethz.source
ECIT
ethz.identifier.importid
imp593654971ca7450884
ethz.ecitpid
pub:180930
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T14:06:45Z
ethz.rosetta.lastUpdated
2021-02-15T01:11:15Z
ethz.rosetta.versionExported
true
ethz.COinS
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