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dc.contributor.author
Alaerts, Kaat
dc.contributor.author
Swinnen, Stephan P.
dc.contributor.author
Wenderoth, Nicole
dc.date.accessioned
2019-10-09T15:05:11Z
dc.date.available
2017-06-12T10:06:32Z
dc.date.available
2019-10-09T15:05:11Z
dc.date.issued
2016
dc.identifier.issn
1749-5016
dc.identifier.issn
1749-5024
dc.identifier.other
10.1093/scan/nsw027
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/118995
dc.identifier.doi
10.3929/ethz-b-000118995
dc.description.abstract
Autism spectrum disorders (ASD) are far more prevalent in males than in females. Little is known however about the differential neural expression of ASD in males and females. We used a resting-state fMRI-dataset comprising 42 males/42 females with ASD and 75 male/75 female typical-controls to examine whether autism-related alterations in intrinsic functional connectivity are similar or different in males and females, and particularly whether alterations reflect ‘neural masculinization’, as predicted by the Extreme Male Brain theory. Males and females showed a differential neural expression of ASD, characterized by highly consistent patterns of hypo-connectivity in males with ASD (compared to typical males), and hyper-connectivity in females with ASD (compared to typical females). Interestingly, patterns of hyper-connectivity in females with ASD reflected a shift towards the (high) connectivity levels seen in typical males (neural masculinization), whereas patterns of hypo-connectivity observed in males with ASD reflected a shift towards the (low) typical feminine connectivity patterns (neural feminization). Our data support the notion that ASD is a disorder of sexual differentiation rather than a disorder characterized by masculinization in both genders. Future work is needed to identify underlying factors such as sex hormonal alterations that drive these sex-specific neural expressions of ASD.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Autism spectrum disorders
en_US
dc.subject
sex differences
en_US
dc.subject
functional connectivity
en_US
dc.subject
resting-state fMRI
en_US
dc.title
Sex differences in autism: A resting-state fMRI investigation of functional brain connectivity in males and females
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2016-03-17
ethz.journal.title
Social Cognitive and Affective Neuroscience
ethz.journal.volume
11
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Soc Cogn Affect Neurosci
ethz.pages.start
1002
en_US
ethz.pages.end
1016
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
005955548
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
ethz.date.deposited
2017-06-12T10:07:23Z
ethz.source
ECIT
ethz.identifier.importid
imp593654983fa7617252
ethz.ecitpid
pub:180982
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-19T10:16:45Z
ethz.rosetta.lastUpdated
2019-10-09T15:05:23Z
ethz.rosetta.versionExported
true
ethz.COinS
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