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dc.contributor.author
Müller, Michael
dc.contributor.author
Öztürk, Ece
dc.contributor.author
Arlov, Øystein
dc.contributor.author
Gatenholm, Paul
dc.contributor.author
Zenobi-Wong, Marcy
dc.date.accessioned
2023-09-29T11:29:00Z
dc.date.available
2017-06-12T10:59:38Z
dc.date.available
2017-07-27T15:03:58Z
dc.date.available
2023-09-29T11:29:00Z
dc.date.issued
2017-01
dc.identifier.issn
0090-6964
dc.identifier.issn
1573-9686
dc.identifier.issn
0191-5649
dc.identifier.other
10.1007/s10439-016-1704-5
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/119497
dc.identifier.doi
10.3929/ethz-b-000119497
dc.description.abstract
One of the challenges of bioprinting is to identify bioinks which support cell growth, tissue maturation, and ultimately the formation of functional grafts for use in regenerative medicine. The influence of this new biofabrication technology on biology of living cells, however, is still being evaluated. Recently we have identified a mitogenic hydrogel system based on alginate sulfate which potently supports chondrocyte phenotype, but is not printable due to its rheological properties (no yield point). To convert alginate sulfate to a printable bioink, it was combined with nanocellulose, which has been shown to possess very good printability. The alginate sulfate/nanocellulose ink showed good printing properties and the non-printed bioink material promoted cell spreading, proliferation, and collagen II synthesis by the encapsulated cells. When the bioink was printed, the biological performance of the cells was highly dependent on the nozzle geometry. Cell spreading properties were maintained with the lowest extrusion pressure and shear stress. However, extruding the alginate sulfate/nanocellulose bioink and chondrocytes significantly compromised cell proliferation, particularly when using small diameter nozzles and valves.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.subject
Bioprinting
en_US
dc.subject
Nanocellulose
en_US
dc.subject
Alginate sulfate
en_US
dc.subject
Cartilage tissue engineering
en_US
dc.title
Alginate Sulfate–Nanocellulose Bioinks for Cartilage Bioprinting Applications
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
dc.date.published
2016-08-08
ethz.journal.title
Annals of biomedical engineering
ethz.journal.volume
45
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Ann. biomed. eng.
ethz.pages.start
210
en_US
ethz.pages.end
223
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
en_US
ethz.grant
A Bio-inspired Cartilage Mimetic with Enhanced Chondrogenic and Anti-inflammatory Properties
en_US
ethz.grant
Drug-induced expression of the chondrogenic phenotype using a nanofiber-reinforced cartilage mimetic
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
000017939
ethz.publication.place
Dordrecht
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03949 - Zenobi-Wong, Marcy / Zenobi-Wong, Marcy
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03949 - Zenobi-Wong, Marcy / Zenobi-Wong, Marcy
ethz.grant.agreementno
159783
ethz.grant.agreementno
143667
ethz.grant.agreementno
159783
ethz.grant.agreementno
143667
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2017-06-12T11:06:25Z
ethz.source
ECIT
ethz.identifier.importid
imp593654a25fffe15222
ethz.ecitpid
pub:181512
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-27T15:04:06Z
ethz.rosetta.lastUpdated
2024-02-03T04:17:17Z
ethz.rosetta.versionExported
true
ethz.COinS
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