A microelectrode array with 8,640 electrodes enabling simultaneous full-frame readout at 6.5 kfps and 112-channel switch-matrix readout at 20 kS/s

Abstract

CMOS microelectrode arrays allow for recording from neurons at thousands of sites. Here, we introduce the concept of a `dual-mode operation' microelectrode array, leveraging the advantages of full-frame scanning and switch-matrix array architectures into a single device. The chip was fabricated in 0.18 μm CMOS technology. Measured noise levels were 11.1 μV rms for full-frame scanning and 1.6 μV rms for switch-matrix mode at 3.3 μW and 38.1 μW per channel power consumption. Recordings of electrical activity from cultured neurons have been successfully conducted.