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dc.contributor.author
Hauri, Simon
dc.contributor.author
Comoglio, Federico
dc.contributor.author
Seimiya, Makiko
dc.contributor.author
Gerstung, Moritz
dc.contributor.author
Glatter, Timo
dc.contributor.author
Hansen, Klaus
dc.contributor.author
Aebersold, Ruedi
dc.contributor.author
Paro, Renato
dc.contributor.author
Gstaiger, Matthias
dc.contributor.author
Beisel, Christian
dc.date.accessioned
2018-09-17T11:44:42Z
dc.date.available
2017-06-12T15:05:55Z
dc.date.available
2018-09-17T11:44:42Z
dc.date.issued
2016-10
dc.identifier.issn
2666-3864
dc.identifier.issn
2211-1247
dc.identifier.other
10.1016/j.celrep.2016.08.096
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/122094
dc.identifier.doi
10.3929/ethz-b-000122094
dc.description.abstract
Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome using a robust affinity purification mass spectrometry approach. Our high-density protein interaction network uncovered a diverse range of PcG complexes. Moreover, our analysis identified PcG interactors linking them to the PcG system, thus providing insight into the molecular function of PcG complexes and mechanisms of recruitment to target genes. We identified two human PRC2 complexes and two PR-DUB deubiquitination complexes, which contain the O-linked N-acetylglucosamine transferase OGT1 and several transcription factors. Finally, genome-wide profiling of PR-DUB components indicated that the human PR-DUB and PRC1 complexes bind distinct sets of target genes, suggesting differential impact on cellular processes in mammals.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Polycomb
en_US
dc.subject
Gene silencing
en_US
dc.subject
AP-MS
en_US
dc.subject
Proteomics
en_US
dc.subject
Epigenetics
en_US
dc.title
A High-Density Map for Navigating the Human Polycomb Complexome
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2016-10-04
ethz.journal.title
Cell Reports
ethz.journal.volume
17
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
Cell Rep
ethz.pages.start
583
en_US
ethz.pages.end
595
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007612702
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03748 - Paro, Renato (emeritus) / Paro, Renato (emeritus)
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03748 - Paro, Renato (emeritus) / Paro, Renato (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
ethz.date.deposited
2017-06-12T15:11:12Z
ethz.source
ECIT
ethz.identifier.importid
imp593654d3d0a5d96158
ethz.ecitpid
pub:184376
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T00:14:17Z
ethz.rosetta.lastUpdated
2022-03-28T21:19:19Z
ethz.rosetta.versionExported
true
ethz.COinS
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