Show simple item record

dc.contributor.author
Fatima Magliarelli, Helena de
dc.contributor.author
Matondo, Mariette
dc.contributor.author
Mészáros, Gergő
dc.contributor.author
Goginashvili, Alexander
dc.contributor.author
Erbs, Eric
dc.contributor.author
Zhang, Zhirong
dc.contributor.author
Mihlan, Michael
dc.contributor.author
Wolfrum, Christian
dc.contributor.author
Wolfrum, Christian
dc.contributor.author
Aebersold, Ruedi
dc.contributor.author
Sumara, Izabela
dc.contributor.author
Ricci, Romeo
dc.date.accessioned
2019-09-09T09:08:17Z
dc.date.available
2017-06-12T16:21:02Z
dc.date.available
2019-09-09T09:08:17Z
dc.date.issued
2016
dc.identifier.issn
2041-4889
dc.identifier.other
10.1038/cddis.2016.312
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/122900
dc.identifier.doi
10.3929/ethz-b-000122900
dc.description.abstract
Adaptation to changes in nutrient availability is crucial for cells and organisms. Posttranslational modifications of signaling proteins are very dynamic and are therefore key to promptly respond to nutrient deprivation or overload. Herein we screened for ubiquitylation of proteins in the livers of fasted and refed mice using a comprehensive systemic proteomic approach. Among 1641 identified proteins, 117 were differentially ubiquitylated upon fasting or refeeding. Endoplasmic reticulum (ER) and secretory proteins were enriched in the livers of refed mice in part owing to an ER-stress-mediated response engaging retro-translocation and ubiquitylation of proteins from the ER. Complement C3, an innate immune factor, emerged as the most prominent ER-related hit of our screen. Accordingly, we found that secretion of C3 from the liver and primary hepatocytes as well as its dynamic trafficking are nutrient dependent. Finally, obese mice with a chronic nutrient overload show constitutive trafficking of C3 in the livers despite acute changes in nutrition, which goes in line with increased C3 levels and low-grade inflammation reported for obese patients. Our study thus suggests that nutrient sensing in the liver is coupled to release of C3 and potentially its metabolic and inflammatory functions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2016-10-13
ethz.journal.title
Cell Death & Disease
ethz.journal.volume
7
en_US
ethz.pages.start
e2411
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
006029226
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03819 - Wolfrum, Christian / Wolfrum, Christian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03819 - Wolfrum, Christian / Wolfrum, Christian
ethz.date.deposited
2017-06-12T16:23:49Z
ethz.source
ECIT
ethz.identifier.importid
imp593654e34a1a576715
ethz.ecitpid
pub:185236
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T00:07:09Z
ethz.rosetta.lastUpdated
2019-09-09T09:08:28Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Liver%20ubiquitome%20uncovers%20nutrient-stress-mediated%20trafficking%20and%20secretion%20of%20complement%20C3&rft.jtitle=Cell%20Death%20&%20Disease&rft.date=2016&rft.volume=7&rft.spage=e2411&rft.issn=2041-4889&rft.au=Fatima%20Magliarelli,%20Helena%20de&Matondo,%20Mariette&M%C3%A9sz%C3%A1ros,%20Gerg%C5%91&Goginashvili,%20Alexander&Erbs,%20Eric&rft.genre=article&rft_id=info:doi/10.1038/cddis.2016.312&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record