Combinatorial microfluidic droplet engineering for biomimetic material synthesis
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
Although droplet-based systems are used in a wide range of technologies, opportunities forsystematicallycustomizingtheir interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidlytailoring emulsion droplet compositions and properties.The approach uses a simple platform for screening arrays ofdroplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Throughthe application of genetic algorithms over multiple screening rounds, dropletswith target properties can be rapidlygenerated. The potential of this method is demonstrated bycreating droplets with enhanced stability, where this isachieved by selecting carrier fluid chemistries that promote titanium dioxide formation at the droplet interfaces. Theinterface is a mixture of amorphous and crystalline phases, and the resulting composite droplets are biocompatible,supporting in vitro protein expression in their interiors. This general strategy will find widespread application inadvancing emulsion properties for use in chemistry, biology, materials, and medicine. Show more
Journal / seriesScience Advances
Pages / Article No.
Organisational unit03914 - deMello, Andrew / deMello, Andrew
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