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dc.contributor.author
Bawazer, Lukmaan A.
dc.contributor.author
McNally, Ciara S.
dc.contributor.author
Empson, Christopher J.
dc.contributor.author
Marchant, William J.
dc.contributor.author
Comyn, Tim P.
dc.contributor.author
Niu, Xize
dc.contributor.author
Cho, Soongwon
dc.contributor.author
McPherson, Michael J.
dc.contributor.author
Binks, Bernard P.
dc.contributor.author
de Mello, Andrew
dc.contributor.author
Meldrum, Fiona C.
dc.date.accessioned
2019-03-27T12:07:49Z
dc.date.available
2017-06-12T16:40:29Z
dc.date.available
2019-03-27T12:07:49Z
dc.date.issued
2016-10
dc.identifier.issn
2375-2548
dc.identifier.other
10.1126/sciadv.1600567
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/123142
dc.identifier.doi
10.3929/ethz-b-000123142
dc.description.abstract
Although droplet-based systems are used in a wide range of technologies, opportunities forsystematicallycustomizingtheir interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidlytailoring emulsion droplet compositions and properties.The approach uses a simple platform for screening arrays ofdroplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Throughthe application of genetic algorithms over multiple screening rounds, dropletswith target properties can be rapidlygenerated. The potential of this method is demonstrated bycreating droplets with enhanced stability, where this isachieved by selecting carrier fluid chemistries that promote titanium dioxide formation at the droplet interfaces. Theinterface is a mixture of amorphous and crystalline phases, and the resulting composite droplets are biocompatible,supporting in vitro protein expression in their interiors. This general strategy will find widespread application inadvancing emulsion properties for use in chemistry, biology, materials, and medicine.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
AAAS
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Combinatorial microfluidic droplet engineering for biomimetic material synthesis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-10-07
ethz.journal.title
Science Advances
ethz.journal.volume
2
en_US
ethz.journal.issue
10
en_US
ethz.journal.abbreviated
Sci Adv
ethz.pages.start
e1600567
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
010666524
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03914 - deMello, Andrew / deMello, Andrew
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03914 - deMello, Andrew / deMello, Andrew
ethz.date.deposited
2017-06-12T16:45:38Z
ethz.source
ECIT
ethz.identifier.importid
imp593654e74bf9734471
ethz.ecitpid
pub:185518
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T15:06:54Z
ethz.rosetta.lastUpdated
2019-03-27T12:08:01Z
ethz.rosetta.versionExported
true
ethz.COinS
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