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dc.contributor.author
Kragl, Martin
dc.contributor.author
Schubert, Rajib
dc.contributor.author
Karsjens, Haiko
dc.contributor.author
Otter, Silke
dc.contributor.author
Bartosinska, Barbara
dc.contributor.author
Jeruschke, Kay
dc.contributor.author
Weiss, Jürgen
dc.contributor.author
Chen, Chunguang
dc.contributor.author
Alsteens, David
dc.contributor.author
Kuss, Oliver
dc.contributor.author
Speier, Stephan
dc.contributor.author
Eberhard, Daniel
dc.contributor.author
Müller, Daniel J.
dc.contributor.author
Lammert, Eckhard
dc.date.accessioned
2018-09-12T12:26:34Z
dc.date.available
2017-06-12T17:18:50Z
dc.date.available
2018-09-12T12:26:34Z
dc.date.issued
2016
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/ncomms13560
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/124146
dc.identifier.doi
10.3929/ethz-b-000124146
dc.description.abstract
An important question is how growing tissues establish a blood vessel network. Here we study vascular network formation in pancreatic islets, endocrine tissues derived from pancreatic epithelium. We find that depletion of integrin-linked kinase (ILK) in the pancreatic epithelial cells of mice results in glucose intolerance due to a loss of the intra-islet vasculature. In turn, blood vessels accumulate at the islet periphery. Neither alterations in endothelial cell proliferation, apoptosis, morphology, Vegfa expression and VEGF-A secretion nor ‘empty sleeves’ of vascular basement membrane are found. Instead, biophysical experiments reveal that the biomechanical properties of pancreatic islet cells, such as their actomyosin-mediated cortex tension and adhesive forces to endothelial cells, are significantly changed. These results suggest that a sorting event is driving the segregation of endothelial and epithelial cells and indicate that the epithelial biomechanical properties determine whether the blood vasculature invades or envelops a growing epithelial tissue.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
The biomechanical properties of an epithelial tissue determine the location of its vasculature
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2016-12-20
ethz.journal.title
Nature Communications
ethz.journal.volume
7
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
13560
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Systematische Charakterisierung der Kommunikation von Zelladhäsionsrezeptoren mittels Einzelzellkraftspektroskopie
en_US
ethz.identifier.wos
ethz.identifier.nebis
007044158
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03870 - Müller, Daniel J. / Müller, Daniel J.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03870 - Müller, Daniel J. / Müller, Daniel J.
ethz.grant.agreementno
138063
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2017-06-12T17:19:43Z
ethz.source
ECIT
ethz.identifier.importid
imp593654f7ea13342133
ethz.ecitpid
pub:186589
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-14T15:02:43Z
ethz.rosetta.lastUpdated
2019-02-03T07:54:51Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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