Zur Kurzanzeige

dc.contributor.author
Moessnang, Carolin
dc.contributor.author
Schäfer, Axel
dc.contributor.author
Bilek, Edda
dc.contributor.author
Roux, Paul
dc.contributor.author
Otto, Kristina
dc.contributor.author
Baumeister, Sarah
dc.contributor.author
Hohmann, Sarah
dc.contributor.author
Poustka, Luise
dc.contributor.author
Brandeis, Daniel
dc.contributor.author
Banaschewski, Tobias
dc.contributor.author
Meyer-Lindenberg, Andreas
dc.contributor.author
Tost, Heike
dc.date.accessioned
2019-10-09T16:42:00Z
dc.date.available
2017-06-12T17:22:25Z
dc.date.available
2019-10-09T16:42:00Z
dc.date.issued
2016-11
dc.identifier.issn
1749-5016
dc.identifier.issn
1749-5024
dc.identifier.other
10.1093/scan/nsw098
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/124236
dc.identifier.doi
10.3929/ethz-b-000124236
dc.description.abstract
The debilitating effects of social dysfunction in many psychiatric disorders prompt the need for systems-level biomarkers of social abilities that can be applied in clinical populations and longitudinal studies. A promising neuroimaging approach is the animated shapes paradigm based on so-called Frith-Happé animations (FHAs) which trigger spontaneous mentalizing with minimal cognitive demands. Here, we presented FHAs during functional magnetic resonance imaging to 46 subjects and examined the specificity and sensitivity of the elicited social brain responses. Test–retest reliability was additionally assessed in 28 subjects within a two-week interval. Specific responses to spontaneous mentalizing were observed in key areas of the social brain with high sensitivity and independently from the variant low-level kinematics of the FHAs. Mentalizing-specific responses were well replicable on the group level, suggesting good-to-excellent cross-sectional reliability [intraclass correlation coefficients (ICCs): 0.40–0.99; dice overlap at Puncorr <0.001: 0.26–1.0]. Longitudinal reliability on the single-subject level was more heterogeneous (ICCs of 0.40–0.79; dice overlap at Puncorr <0.001: 0.05–0.43). Posterior temporal sulcus activation was most reliable, including a robust differentiation between subjects across sessions (72% of voxels with ICC>0.40). These findings encourage the use of FHAs in neuroimaging research across developmental stages and psychiatric conditions, including the identification of biomarkers and pharmacological interventions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Spontaneous mentalizing
en_US
dc.subject
fMRI
en_US
dc.subject
Animated shapes
en_US
dc.subject
Reliability
en_US
dc.subject
biomarker
en_US
dc.title
Specificity, reliability and sensitivity of social brain responses during spontaneous mentalizing
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
ethz.journal.title
Social Cognitive and Affective Neuroscience
ethz.journal.volume
11
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
Soc Cogn Affect Neurosci
ethz.pages.start
1687
en_US
ethz.pages.end
1697
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005955548
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-12T17:23:24Z
ethz.source
ECIT
ethz.identifier.importid
imp593654f9ce2e930086
ethz.ecitpid
pub:186691
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T14:42:03Z
ethz.rosetta.lastUpdated
2019-10-09T16:42:17Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.atitle=Specificity,%20reliability%20and%20sensitivity%20of%20social%20brain%20responses%20during%20spontaneous%20mentalizing&amp;rft.jtitle=Social%20Cognitive%20and%20Affective%20Neuroscience&amp;rft.date=2016-11&amp;rft.volume=11&amp;rft.issue=11&amp;rft.spage=1687&amp;rft.epage=1697&amp;rft.issn=1749-5016&amp;1749-5024&amp;rft.au=Moessnang,%20Carolin&amp;Sch%C3%A4fer,%20Axel&amp;Bilek,%20Edda&amp;Roux,%20Paul&amp;Otto,%20Kristina&amp;rft.genre=article&amp;
 Suchen via SFX

Dateien zu diesem Eintrag

Thumbnail

Publikationstyp

Zur Kurzanzeige