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dc.contributor.author
Antsiferova, Maria
dc.contributor.author
Piwko-Czuchra, Aleksandra
dc.contributor.author
Cangkrama, Michael
dc.contributor.author
Wietecha, Mateusz
dc.contributor.author
Sahin, Dilara
dc.contributor.author
Birkner, Katharina
dc.contributor.author
Amann, Valerie C.
dc.contributor.author
Levesque, Mitchell
dc.contributor.author
Hohl, Daniel
dc.contributor.author
Dummer, Reinhard
dc.contributor.author
Werner, Sabine
dc.date.accessioned
2019-08-21T12:26:53Z
dc.date.available
2017-06-12T17:22:29Z
dc.date.available
2019-08-21T12:26:53Z
dc.date.issued
2017-01-01
dc.identifier.issn
1757-4676
dc.identifier.issn
1757-4684
dc.identifier.other
10.15252/emmm.201606493
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/124243
dc.identifier.doi
10.3929/ethz-b-000124243
dc.description.abstract
Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is an early event in murine and human skin tumorigenesis. This is functionally important, since activin promoted skin tumorigenesis in mice induced by the human papillomavirus 8 oncogenes. This was accompanied by depletion of epidermal γδ T cells and accumulation of regulatory T cells. Most importantly, activin increased the number of skin macrophages via attraction of blood monocytes, which was prevented by depletion of CCR2‐positive monocytes. Gene expression profiling of macrophages from pre‐tumorigenic skin and bioinformatics analysis demonstrated that activin induces a gene expression pattern in skin macrophages that resembles the phenotype of tumor‐associated macrophages in different malignancies, thereby promoting angiogenesis, cell migration and proteolysis. The functional relevance of this finding was demonstrated by antibody‐mediated depletion of macrophages, which strongly suppressed activin‐induced skin tumor formation. These results demonstrate that activin induces skin carcinogenesis via attraction and reprogramming of macrophages and identify novel activin targets involved in tumor formation.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Activin
en_US
dc.subject
Macrophage
en_US
dc.subject
Skin Cancer
en_US
dc.subject
Tumor microenvironment
en_US
dc.title
Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2016-12-08
ethz.journal.title
EMBO Molecular Medicine
ethz.journal.volume
9
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
EMBO Mol Med
ethz.pages.start
27
en_US
ethz.pages.end
45
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
005874008
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
ethz.date.deposited
2017-06-12T17:23:24Z
ethz.source
ECIT
ethz.identifier.importid
imp593654f9e961c50106
ethz.ecitpid
pub:186698
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T03:49:54Z
ethz.rosetta.lastUpdated
2019-08-21T12:27:08Z
ethz.rosetta.versionExported
true
ethz.COinS
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