Zur Kurzanzeige

dc.contributor.author
Diaconescu, Andreea O.
dc.contributor.author
Mathys, Christoph
dc.contributor.author
Weber, Lilian A.E.
dc.contributor.author
Kasper, Lars
dc.contributor.author
Mauer, Jan
dc.contributor.author
Stephan, Klaas E.
dc.date.accessioned
2019-10-09T15:49:35Z
dc.date.available
2017-06-12T17:22:59Z
dc.date.available
2019-10-09T15:49:35Z
dc.date.issued
2017-04
dc.identifier.issn
1749-5016
dc.identifier.issn
1749-5024
dc.identifier.other
10.1093/scan/nsw171
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/124291
dc.identifier.doi
10.3929/ethz-b-000124291
dc.description.abstract
Social learning is fundamental to human interactions, yet its computational and physiological mechanisms are not well understood. One prominent open question concerns the role of neuromodulatory transmitters. We combined fMRI, computational modelling and genetics to address this question in two separate samples (N = 35, N = 47). Participants played a game requiring inference on an adviser’s intentions whose motivation to help or mislead changed over time. Our analyses suggest that hierarchically structured belief updates about current advice validity and the adviser’s trustworthiness, respectively, depend on different neuromodulatory systems. Low-level prediction errors (PEs) about advice accuracy not only activated regions known to support ‘theory of mind’, but also the dopaminergic midbrain. Furthermore, PE responses in ventral striatum were influenced by the Met/Val polymorphism of the Catechol-O-Methyltransferase (COMT) gene. By contrast, high-level PEs (‘expected uncertainty’) about the adviser’s fidelity activated the cholinergic septum. These findings, replicated in both samples, have important implications: They suggest that social learning rests on hierarchically related PEs encoded by midbrain and septum activity, respectively, in the same manner as other forms of learning under volatility. Furthermore, these hierarchical PEs may be broadcast by dopaminergic and cholinergic projections to induce plasticity specifically in cortical areas known to represent beliefs about others.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Hierarchical prediction errors
en_US
dc.subject
Theory of mind
en_US
dc.subject
Bayesian inference
en_US
dc.subject
fMRI
en_US
dc.subject
dopamine
en_US
dc.subject
COMT
en_US
dc.title
Hierarchical prediction errors in midbrain and septum during social learning
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2017-01-24
ethz.journal.title
Social Cognitive and Affective Neuroscience
ethz.journal.volume
12
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Soc Cogn Affect Neurosci
ethz.pages.start
618
en_US
ethz.pages.end
634
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005955548
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.date.deposited
2017-06-12T17:23:24Z
ethz.source
ECIT
ethz.identifier.importid
imp593654faebd0591823
ethz.ecitpid
pub:186765
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-14T15:31:05Z
ethz.rosetta.lastUpdated
2019-10-09T15:49:51Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Hierarchical%20prediction%20errors%20in%20midbrain%20and%20septum%20during%20social%20learning&rft.jtitle=Social%20Cognitive%20and%20Affective%20Neuroscience&rft.date=2017-04&rft.volume=12&rft.issue=4&rft.spage=618&rft.epage=634&rft.issn=1749-5016&1749-5024&rft.au=Diaconescu,%20Andreea%20O.&Mathys,%20Christoph&Weber,%20Lilian%20A.E.&Kasper,%20Lars&Mauer,%20Jan&rft.genre=article&
 Suchen via SFX

Dateien zu diesem Eintrag

Thumbnail

Publikationstyp

Zur Kurzanzeige