- Journal Article
Rights / licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
Apolipoprotein nanodiscs are a versatile tool in nanotechnology as membrane mimetics allowing, for example, the study of membrane proteins. It has recently been discovered that the Parkinson’s disease associated protein α-synuclein (α-Syn) can also form discoid-like lipoprotein nanoparticles. The present review highlights the observation that α-Syn has the properties to define stable and homogeneous populations of nanoparticles with diameters of 7–10 nm and 19–28 nm by modifying lipid vesicles or encapsulating lipid bilayers in a nanodisc-type fashion, respectively. In contrast to apolipoprotein nanodiscs, α-Syn nanoparticles can incorporate entirely negatively charged lipids emphasizing their potential use in nanotechnology as a negatively charged membrane mimetic. Show more
Journal / seriesNanotechnology Reviews
Pages / Article No.
SubjectLipoprotein; Nanodiscs; NMR; Parkinson's disease; α-synuclein
Organisational unit03782 - Riek, Roland / Riek, Roland
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