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dc.contributor.author
Špolcová, Andrea
dc.contributor.author
Mikulášková, Barbora
dc.contributor.author
Kršková, Katarína
dc.contributor.author
Gajdošechová, Lucia
dc.contributor.author
Zórad, Štefan
dc.contributor.author
Olszanecki, Rafał
dc.contributor.author
Suski, Maciej
dc.contributor.author
Bujak-Giżycka, Beata
dc.contributor.author
Železná, Blanka
dc.contributor.author
Maletínská, Lenka
dc.date.accessioned
2019-04-12T10:55:00Z
dc.date.available
2017-06-12T18:29:47Z
dc.date.available
2019-04-12T10:55:00Z
dc.date.issued
2014-09-25
dc.identifier.issn
1471-2202
dc.identifier.other
10.1186/1471-2202-15-111
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/126381
dc.identifier.doi
10.3929/ethz-b-000126381
dc.description.abstract
Background Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resistance and aging are risk factors for central insulin resistance and whether central insulin resistance is related to the pathologic phosphorylation of the Tau protein. Results Aging and obesity significantly attenuated the phosphorylation of the insulin cascade kinases Akt (protein kinase B, PKB) and GSK-3β (glycogen synthase kinase 3β) in the hippocampi of the fa/fa rats. Furthermore, the hyperphosphorylation of Tau Ser396 alone and both Tau Ser396 and Thr231 was significantly augmented by aging and obesity, respectively, in the hippocampi of these rats. Conclusions Both age-induced and obesity-induced peripheral insulin resistance are associated with central insulin resistance that is linked to hyperTau phosphorylation. Peripheral hyperinsulinemia, rather than hyperglycemia, appears to promote central insulin resistance and the Tau pathology in fa/fa rats.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/2.0/
dc.subject
Zucker fa/fa rats
en_US
dc.subject
Insulin resistance
en_US
dc.subject
Obesity
en_US
dc.subject
GSK-3β
en_US
dc.subject
Tau protein
en_US
dc.title
Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 2.0 Generic
ethz.journal.title
BMC Neuroscience
ethz.journal.volume
15
en_US
ethz.journal.abbreviated
BMC neurosci. (Online)
ethz.pages.start
111
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.nebis
004407033
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-12T18:30:32Z
ethz.source
ECIT
ethz.identifier.importid
imp5936551f2aafd75574
ethz.ecitpid
pub:189112
ethz.eth
no
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-17T09:11:51Z
ethz.rosetta.lastUpdated
2020-02-15T18:25:48Z
ethz.rosetta.versionExported
true
ethz.COinS
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