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dc.contributor.author
Barardo, Diogo
dc.contributor.author
Thornton, Daniel
dc.contributor.author
Thoppil, Harikrishnan
dc.contributor.author
Walsh, Michael
dc.contributor.author
Sharifi, Samim
dc.contributor.author
Ferreira, Susana
dc.contributor.author
Anžič, Andreja
dc.contributor.author
Fernandes, Maria
dc.contributor.author
Monteiro, Patrick
dc.contributor.author
Grum, Tjaša
dc.contributor.author
Cordeiro, Rui
dc.contributor.author
De-Souza, Evandro A.
dc.contributor.author
Budovsky, Arie
dc.contributor.author
Araujo, Natali
dc.contributor.author
Gruber, jan
dc.contributor.author
Petrascheck, Michael
dc.contributor.author
Fraifeld, Vadim E.
dc.contributor.author
Zhavoronkov, Alexander
dc.contributor.author
Moskalev, Alexey
dc.contributor.author
de Magalhães, João P.
dc.date.accessioned
2017-11-13T17:00:46Z
dc.date.available
2017-06-12T20:22:42Z
dc.date.available
2017-07-31T16:58:00Z
dc.date.available
2017-07-31T17:07:29Z
dc.date.available
2017-11-13T17:00:46Z
dc.date.issued
2017-06
dc.identifier.issn
1474-9718
dc.identifier.issn
1474-9728
dc.identifier.issn
1474-9726
dc.identifier.other
10.1111/acel.12585
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/129629
dc.identifier.doi
10.3929/ethz-b-000129629
dc.description.abstract
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug–gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley-Blackwell
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Bioinformatics
en_US
dc.subject
Compound
en_US
dc.subject
Functional genomics
en_US
dc.subject
Lifespan
en_US
dc.subject
Longevity
en_US
dc.subject
Pharmacology
en_US
dc.title
The DrugAge database of aging-related drugs
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-03-16
ethz.journal.title
Aging Cell
ethz.journal.volume
16
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
Aging cell
ethz.pages.start
594
en_US
ethz.pages.end
597
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
004513522
ethz.publication.place
Hoboken, NJ
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-12T20:22:48Z
ethz.source
ECIT
ethz.identifier.importid
imp593655587591135226
ethz.ecitpid
pub:192613
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-31T16:58:10Z
ethz.rosetta.lastUpdated
2017-11-13T17:00:52Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=The%20DrugAge%20database%20of%20aging-related%20drugs&rft.jtitle=Aging%20Cell&rft.date=2017-06&rft.volume=16&rft.issue=3&rft.spage=594&rft.epage=597&rft.issn=1474-9718&1474-9728&1474-9726&rft.au=Barardo,%20Diogo&Thornton,%20Daniel&Thoppil,%20Harikrishnan&Walsh,%20Michael&Sharifi,%20Samim&rft.genre=article&
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