Synthesis and stabilities of peptide-based rotaxanes: molecular grafting onto lasso peptide scaffolds
Bode, Jeffrey W.
- Journal Article
Rights / licenseCreative Commons Attribution-NonCommercial 3.0 Unported
The chemical synthesis of peptide-based rotaxanes (lasso peptides) was achieved by rotaxane formation followed by two chemoselective ligation reactions. Our approach enabled incorporation of various peptide sequences into a common rotaxane structure. The synthetic lasso peptides were characterized by NMR, chromatography, and partial degradation by proteases. A linear peptide epitope grafted onto the rotaxane scaffold showed significantly improved proteolytic stability Show more
Journal / seriesChemical Science
Pages / Article No.
PublisherRoyal Society of Chemistry
Organisational unit03861 - Bode, Jeffrey W. / Bode, Jeffrey W.
MoreShow all metadata