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dc.contributor.author
Xu, Shuqing
dc.contributor.author
Clark, Terry
dc.contributor.author
Zheng, Hongkun
dc.contributor.author
Vang, Søren
dc.contributor.author
Li, Ruiqiang
dc.contributor.author
Wong, Gane Ka-Shu
dc.contributor.author
Wang, Jun
dc.contributor.author
Zheng, Xiaoguang
dc.date.accessioned
2018-10-31T12:51:02Z
dc.date.available
2017-06-13T07:53:25Z
dc.date.available
2017-07-05T06:59:53Z
dc.date.available
2018-10-31T12:51:02Z
dc.date.issued
2008
dc.identifier.other
10.1186/1471-2164-9-93
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/150954
dc.identifier.doi
10.3929/ethz-a-005751615
dc.description.abstract
Background Gene conversion causes a non-reciprocal transfer of genetic information between similar sequences. Gene conversion can both homogenize genes and recruit point mutations thereby shaping the evolution of multigene families. In the rice genome, the large number of duplicated genes increases opportunities for gene conversion. Results To characterize gene conversion in rice, we have defined 626 multigene families in which 377 gene conversions were detected using the GENECONV program. Over 60% of the conversions we detected were between chromosomes. We found that the inter-chromosomal conversions distributed between chromosome 1 and 5, 2 and 6, and 3 and 5 are more frequent than genome average (Z-test, P < 0.05). The frequencies of gene conversion on the same chromosome decreased with the physical distance between gene conversion partners. Ka/Ks analysis indicates that gene conversion is not tightly linked to natural selection in the rice genome. To assess the contribution of segmental duplication on gene conversion statistics, we determined locations of conversion partners with respect to inter-chromosomal segment duplication. The number of conversions associated with segmentation is less than ten percent. Pseudogenes in the rice genome with low similarity to Arabidopsis genes showed greater likelihood for gene conversion than those with high similarity to Arabidopsis genes. Functional annotations suggest that at least 14 multigene families related to disease or bacteria resistance were involved in conversion events. Conclusion The evolution of gene families in the rice genome may have been accelerated by conversion with pseudogenes. Our analysis suggests a possible role for gene conversion in the evolution of pathogen-response genes.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/2.0/
dc.subject
Gene pair
en_US
dc.subject
Rice genome
en_US
dc.subject
Gene conversion
en_US
dc.subject
Multigene family
en_US
dc.subject
Segmental duplication
en_US
dc.title
Gene conversion in the rice genome
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 2.0 Generic
dc.date.published
2018-02-25
ethz.journal.title
BMC Genomics
ethz.journal.volume
9
en_US
ethz.pages.start
93
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.code.ddc
DDC - DDC::5 - Science::570 - Life sciences
en_US
ethz.identifier.nebis
005751615
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology
en_US
ethz.date.deposited
2017-06-13T07:57:59Z
ethz.source
ECOL
ethz.identifier.importid
imp59366acd67f5346212
ethz.ecolpid
eth:41371
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-05T07:00:06Z
ethz.rosetta.lastUpdated
2020-02-15T15:43:16Z
ethz.rosetta.versionExported
true
ethz.COinS
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