Search
Results
-
The Dynamics of Occupational Career Trajectories
(2022)Contemporary careers are characterized by manifold socio-economic and technological transformations, that will transform work design across virtually all occupations. Considering such rapid developments, individuals have to adapt to ever changing work environments within their occupations, or, alternatively, pursue different career paths and exit their occupations. Yet, occupations are fundamental reference points that guide individual ...Doctoral Thesis -
-
Leveraging self-organizing maps with convolutional neural networks for virtual chemical library screening
(2022)Computer assisted drug design has been established as an important tool to support drug discovery projects through the efficient identification of relationships between small molecules and macromolecular targets. Machine learning (ML) algorithms in particular now play an integral role for hit identification screening campaigns due to their capability to screen large databases for promising new chemical entities and to reduce those large ...Doctoral Thesis -
Image-based computational analysis of branching morphogenesis in lung and kidney development
(2022)How the immense multitude of different patterns and shapes in an organism emerges from a nearly uniform fertilized egg constitutes a fundamental question in developmental biology. A fascinating example of a pattern-forming process is branching morphogenesis, which describes the generation of highly ramified epithelial tissue frameworks during the embryonic development of many metazoan organs, such as the lungs and kidneys. Although branching ...Doctoral Thesis -
-
-
-