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- Master Thesis
Rights / licenseCreative Commons Attribution 4.0 International
We designed a model to represent the branching process in single-layer epithelia in 3D. A new tissue model with low resolution and complexity, to make it usable in 3D and on populations of several thousands cells, was implemented and combined with a signaling model based on a receptor-ligand Turing mechanism. These two components can be used independently but were designed to be coupled. Cells in the tissue model are represented as pair of points, where one point stands for the apical side and the other for the basal side of the cell. Cell rearrangements and proliferation obey deterministic rules in the whole domain. The signaling model is based on a Finite Element method and uses the open source library deal.II. Due to its computational complexity, it has been implemented in parallel. Variations of the branching process in response to different changes in the tissue model have been studied in detail. The coupling with the signaling is also studied. This model was built to be easily adaptable and extendable to other processes or tissue dynamics, and is intended to be a base for future work Show more
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ContributorsSupervisor: Iber, Dagmar
Organisational unit02060 - Departement Biosysteme / Department of Biosystems Science and Engineering
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