Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Open access
Date
2017-01Type
- Journal Article
ETH Bibliography
yes
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Abstract
Recent studies have demonstrated that the bacterial chaperone and serine protease high temperature requirement A (HtrA) is closely associated with the establishment and progression of several infectious diseases. HtrA activity enhances bacterial survival under stress conditions, but also has direct effects on functions of the cell adhesion protein E-cadherin and extracellular matrix proteins, including fibronectin and proteoglycans. Although HtrA cannot be considered as a pathogenic factor per se, it exhibits favorable characteristics making HtrA a potentially attractive drug target to combat various bacterial infections. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000187297Publication status
publishedJournal / series
Cell Communication and SignalingVolume
Pages / Article No.
Publisher
BioMed CentralOrganisational unit
03852 - Schneider, Gisbert / Schneider, Gisbert
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ETH Bibliography
yes
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