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dc.contributor.author
Gong, Yuanhao
dc.contributor.author
Andina, Diana
dc.contributor.author
Nahar, Samsun
dc.contributor.author
Leroux, Jean-Christophe
dc.contributor.author
Gauthier, Marc A.
dc.date.accessioned
2017-11-16T16:58:33Z
dc.date.available
2017-10-06T02:11:36Z
dc.date.available
2017-11-16T16:58:33Z
dc.date.issued
2017-05-01
dc.identifier.issn
2041-6520
dc.identifier.issn
2041-6539
dc.identifier.other
10.1039/c7sc00770a
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/190550
dc.identifier.doi
10.3929/ethz-b-000190550
dc.description.abstract
Arginine-rich antimicrobial peptides (AMPs) are emerging therapeutics of interest. However, their applicability is limited by their short circulation half-life, caused in part by their small size and digestion by blood proteases. This study reports a strategy to temporarily mask arginine residues within AMPs with methoxy poly(ethylene glycol). Based on the reagent used, release of AMPs occurred in hours to days in a completely traceless fashion. In vitro, conjugates were insensitive to serum proteases, and released native AMP with full in vitro bioactivity. This strategy is thus highly relevant and should be adaptable to the entire family of arginine-rich AMPs. It may potentially be used to improve AMP-therapies by providing a more steady concentration of AMP in the blood after a single injection, avoiding toxic effects at high AMP doses, and reducing the number of doses required over the treatment duration.
en_US
dc.language.iso
en
en_US
dc.publisher
Royal Society of Chemistry
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Releasable and traceless PEGylation of arginine-rich antimicrobial peptides
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2017-03-30
ethz.journal.title
Chemical Science
ethz.journal.volume
8
en_US
ethz.journal.issue
5
en_US
ethz.journal.abbreviated
Chem. sci.
ethz.pages.start
4082
en_US
ethz.pages.end
4086
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03811 - Leroux, Jean-Christophe / Leroux, Jean-Christophe
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03811 - Leroux, Jean-Christophe / Leroux, Jean-Christophe
ethz.date.deposited
2017-10-06T02:11:39Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-16T16:58:35Z
ethz.rosetta.lastUpdated
2018-11-06T02:00:28Z
ethz.rosetta.versionExported
true
ethz.COinS
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