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dc.contributor.author
Gilberto, Samuel
dc.contributor.author
Peter, Matthias
dc.date.accessioned
2017-12-05T14:22:29Z
dc.date.available
2017-10-06T02:19:48Z
dc.date.available
2017-11-06T14:11:12Z
dc.date.available
2017-12-05T14:22:29Z
dc.date.issued
2017-08
dc.identifier.issn
0021-9525
dc.identifier.issn
1540-8140
dc.identifier.other
10.1083/jcb.201703170
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/190657
dc.identifier.doi
10.3929/ethz-b-000190657
dc.description.abstract
The cell division cycle is driven by a collection of enzymes that coordinate DNA duplication and separation, ensuring that genomic information is faithfully and perpetually maintained. The activity of the effector proteins that perform and coordinate these biological processes oscillates by regulated expression and/or posttranslational modifications. Ubiquitylation is a cardinal cellular modification and is long known for driving cell cycle transitions. In this review, we emphasize emerging concepts of how ubiquitylation brings the necessary dynamicity and plasticity that underlie the processes of DNA replication and mitosis. New studies, often focusing on the regulation of chromosomal proteins like DNA polymerases or kinetochore kinases, are demonstrating that ubiquitylation is a versatile modification that can be used to fine-tune these cell cycle events, frequently through processes that do not involve proteasomal degradation. Understanding how the increasing variety of identified ubiquitin signals are transduced will allow us to develop a deeper mechanistic perception of how the multiple factors come together to faithfully propagate genomic information. Here, we discuss these and additional conceptual challenges that are currently under study toward understanding how ubiquitin governs cell cycle regulation.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
Rockefeller University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.title
Dynamic ubiquitin signaling in cell cycle regulation
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
dc.date.published
2017-07-06
ethz.journal.title
The Journal of Cell Biology
ethz.journal.volume
216
en_US
ethz.journal.issue
8
en_US
ethz.journal.abbreviated
J. Cell Biol.
ethz.pages.start
2259
en_US
ethz.pages.end
2271
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02517 - Institut für Biochemie / Institute of Biochemistry (IBC)::03595 - Peter, Matthias / Peter, Matthias
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02517 - Institut für Biochemie / Institute of Biochemistry (IBC)::03595 - Peter, Matthias / Peter, Matthias
ethz.date.deposited
2017-10-06T02:19:57Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-06T14:11:16Z
ethz.rosetta.lastUpdated
2021-02-14T21:08:54Z
ethz.rosetta.versionExported
true
ethz.COinS
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