Gauy, Marcelo M.
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
Hebbian changes of excitatory synapses are driven by and enhance correlations between pre- and postsynaptic neuronal activations, forming a positive feedback loop that can lead to instability in simulated neural networks. Because Hebbian learning may occur on time scales of seconds to minutes, it is conjectured that some form of fast stabilization of neural firing is necessary to avoid runaway of excitation, but both the theoretical underpinning and the biological implementation for such homeostatic mechanism are to be fully investigated. Supported by analytical and computational arguments, we show that a Hebbian spike-timing-dependent metaplasticity rule, accounts for inherently-stable, quick tuning of the total input weight of a single neuron in the general scenario of asynchronous neural firing characterized by UP and DOWN states of activity Show more
Journal / seriesFrontiers in computational neuroscience
Pages / Article No.
PublisherFrontiers Research Foundation
SubjectSTDP; synapse memory; homeostasis; metaplasticity; synchrony; oscillations
Organisational unit03672 - Steger, Angelika
143337 - Adaptive Relational Networks: A Detailed Model for Effective Cortical Computation (SNF)
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