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dc.contributor.author
Bögli, Stefan Y.
dc.contributor.author
Afthinos, Maresa
dc.contributor.author
Huang, Melody Ying-Yu
dc.date.accessioned
2017-12-05T14:15:48Z
dc.date.available
2017-10-06T02:30:25Z
dc.date.available
2017-11-06T16:30:30Z
dc.date.available
2017-12-05T14:15:48Z
dc.date.issued
2017-06
dc.identifier.issn
0146-0404
dc.identifier.other
10.1167/iovs.16-21308
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/190818
dc.identifier.doi
10.3929/ethz-b-000190818
dc.description.abstract
Purpose: Infantile nystagmus syndrome (INS) is a disorder characterized by typical horizontal eye oscillations. Due to the uncertain etiology of INS, developing specific treatments remains difficult. Single reports demonstrated, on limited measures, alleviating effects of gabapentin and memantine. In the current study, we employed the zebrafish INS model belladonna (bel) to conduct an in-depth study of how gabapentin and memantine interventions alleviate INS signs, which may further restore visual conditions in affected subjects. Moreover, we described the influence of both medications on ocular motor functions in healthy zebrafish, evaluating possible iatrogenic effects. Methods: Ocular motor function and INS characteristics were assessed by eliciting optokinetic response, spontaneous nystagmus, and spontaneous saccades in light and in dark, in 5- to 6-day postfertilization bel larvae and heterozygous siblings. Single larvae were recorded before and after a 1-hour drug treatment (200 mM gabapentin/0.2 mM memantine). Results: Both interventions significantly reduced nystagmus intensity (gabapentin: 59.98%, memantine: 39.59%). However, while the application of gabapentin affected all tested ocular motor functions, memantine specifically reduced nystagmus amplitude and intensity, and thus left controls completely unaffected. Finally, both drug treatments resulted in specific changes in nystagmus waveform and velocity. Conclusions: Our study provides deeper insight into gabapentin and memantine treatment effect in the zebrafish INS model. Moreover, this study should establish zebrafish as a pharmacologic animal model for treating nystagmus and ocular motor disease, serving as a basis for future large-scale drug screenings.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
Association for Research in Vision and Ophthalmology
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
translational medicine
en_US
dc.subject
memantine
en_US
dc.subject
zebrafish
en_US
dc.subject
infantile nystagmus syndrome
en_US
dc.subject
gabapentin
en_US
dc.title
Effect of Gabapentin/Memantine on the Infantile Nystagmus Syndrome in the Zebrafish Model: Implications for the Therapy of Ocular Motor Diseases
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
Investigative Ophthalmology & Visual Science
ethz.journal.volume
58
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
Invest Ophthalmol Vis Sci
ethz.pages.start
3149
en_US
ethz.pages.end
3157
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Hagerstown
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T02:30:35Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-06T16:30:39Z
ethz.rosetta.lastUpdated
2023-02-06T14:57:08Z
ethz.rosetta.versionExported
true
ethz.COinS
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