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dc.contributor.author
Bianconi, Daniela
dc.contributor.author
Heller, Gerwin
dc.contributor.author
Spies, Daniel
dc.contributor.author
Herac, Merima
dc.contributor.author
Gleiss, Andreas
dc.contributor.author
Liebmann-Reindl, Sandra
dc.contributor.author
Unseld, Matthias
dc.contributor.author
Kieler, Markus
dc.contributor.author
Scheithauer, Werner
dc.contributor.author
Streubel, Berthold
dc.contributor.author
Zielinski, Christoph C.
dc.contributor.author
Prager, Gerald W.
dc.date.accessioned
2017-11-15T14:50:30Z
dc.date.available
2017-10-06T02:52:50Z
dc.date.available
2017-11-15T14:50:30Z
dc.date.issued
2017-07-07
dc.identifier.other
10.1038/s41598-017-04743-0
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191131
dc.identifier.doi
10.3929/ethz-b-000191131
dc.description.abstract
Pancreatic cancer is a dismal disease with a mortality rate almost similar to its incidence rate. To date, there are neither validated predictive nor prognostic biomarkers for this lethal disease. Thus, the aim of the present study was to retrospectively investigate the capability of biochemical parameters and molecular profiles to predict survival of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) who participated in a phase II clinical trial to test the safety and efficacy of the combination treatment of capecitabine plus nab-paclitaxel. Herein, we investigated the association of 18 biochemical parameters obtained from routine diagnosis and the clinical outcome of the 30 patients enrolled in the clinical trial. Furthermore, we analysed formalin-fixed paraffin-embedded (FFPE) tumour tissue to identify molecular biomarkers via RNA seq and the Illumina TruSeq Amplicon Cancer panel which covers 48 hotspot genes. Our analysis identified SERPINB7 as a novel transcript and a DNA mutation signature that might predict a poor outcome of disease. Moreover, we identified the bilirubin basal level as an independent predictive factor for overall survival in our study cohort.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Biochemical and genetic predictors of overall survival in patients with metastatic pancreatic cancer treated with capecitabine and nabpaclitaxel
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Scientific Reports
ethz.journal.volume
7
en_US
ethz.pages.start
4851
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T02:53:09Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-15T14:54:38Z
ethz.rosetta.lastUpdated
2019-01-02T10:47:59Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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