Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division
Banerjee, Jennifer J.
Aerne, Birgit L.
Holder, Maxine V.
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery. Show more
Journal / serieseLife
Pages / Article No.
PublishereLife Sciences Publications
115766 - Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery (EC)
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