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dc.contributor.author
Banerjee, Jennifer J.
dc.contributor.author
Aerne, Birgit L.
dc.contributor.author
Holder, Maxine V.
dc.contributor.author
Hauri, Simon
dc.contributor.author
Gstaiger, Matthias
dc.contributor.author
Tapon, Nicolas
dc.date.accessioned
2018-03-27T08:30:10Z
dc.date.available
2017-10-06T02:59:06Z
dc.date.available
2017-10-16T10:05:22Z
dc.date.available
2017-10-26T06:49:30Z
dc.date.available
2018-03-27T08:30:10Z
dc.date.issued
2017-06-30
dc.identifier.other
10.7554/eLife.25014
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191249
dc.identifier.doi
10.3929/ethz-b-000191249
dc.description.abstract
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
eLife
ethz.journal.volume
6
en_US
ethz.pages.start
e25014
en_US
ethz.size
21 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.grant.agreementno
115766
ethz.grant.fundername
EC
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.program
FP7
ethz.date.deposited
2017-10-06T02:59:09Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-10-16T10:05:39Z
ethz.rosetta.lastUpdated
2018-11-06T16:50:06Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Meru%20couples%20planar%20cell%20polarity%20with%20apical-basal%20polarity%20during%20asymmetric%20cell%20division&rft.jtitle=eLife&rft.date=2017-06-30&rft.volume=6&rft.spage=e25014&rft.au=Banerjee,%20Jennifer%20J.&Aerne,%20Birgit%20L.&Holder,%20Maxine%20V.&Hauri,%20Simon&Gstaiger,%20Matthias&rft.genre=article&
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