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dc.contributor.author
Kollmannsberger, Philip
dc.contributor.author
Kerschnitzki, Michael
dc.contributor.author
Repp, Felix
dc.contributor.author
Wagermaier, Wolfgang
dc.contributor.author
Weinkamer, Richard
dc.contributor.author
Fratzl, Peter
dc.date.accessioned
2017-12-05T14:00:32Z
dc.date.available
2017-10-06T03:06:03Z
dc.date.available
2017-11-07T15:51:02Z
dc.date.available
2017-12-05T14:00:32Z
dc.date.issued
2017-07
dc.identifier.issn
1367-2630
dc.identifier.other
10.1088/1367-2630/aa764b
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191337
dc.identifier.doi
10.3929/ethz-b-000191337
dc.description.abstract
Osteocytes and their cell processes reside in a large, interconnected network of voids pervading the mineralized bone matrix of most vertebrates. This osteocyte lacuno-canalicular network (OLCN) is believed to play important roles in mechanosensing, mineral homeostasis, and for the mechanical properties of bone. While the extracellular matrix structure of bone is extensively studied on ultrastructural and macroscopic scales, there is a lack of quantitative knowledge on how the cellular network is organized. Using a recently introduced imaging and quantification approach, we analyze the OLCN in different bone types from mouse and sheep that exhibit different degrees of structural organization not only of the cell network but also of the fibrous matrix deposited by the cells. We define a number of robust, quantitative measures that are derived from the theory of complex networks. These measures enable us to gain insights into how efficient the network is organized with regard to intercellular transport and communication. Our analysis shows that the cell network in regularly organized, slow-growing bone tissue from sheep is less connected, but more efficiently organized compared to irregular and fast-growing bone tissue from mice. On the level of statistical topological properties (edges per node, edge length and degree distribution), both network types are indistinguishable, highlighting that despite pronounced differences at the tissue level, the topological architecture of the osteocyte canalicular network at the subcellular level may be independent of species and bone type. Our results suggest a universal mechanism underlying the self-organization of individual cells into a large, interconnected network during bone formation and mineralization.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
Institute of Physics Publishing Ltd.
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
biomaterials
en_US
dc.subject
bone
en_US
dc.subject
mechanobiology
en_US
dc.subject
networks
en_US
dc.subject
osteocytes
en_US
dc.subject
image analysis
en_US
dc.title
The small world of osteocytes: connectomics of the lacuno-canalicular network in bone
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2017-07-18
ethz.journal.title
New Journal of Physics
ethz.journal.volume
19
en_US
ethz.journal.abbreviated
New j. phys.
ethz.pages.start
073019
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Bristol
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T03:06:05Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-07T15:51:07Z
ethz.rosetta.lastUpdated
2017-12-05T14:00:39Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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