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dc.contributor.author
Holz, Nathalie E.
dc.contributor.author
Boecker-Schlier, Regina
dc.contributor.author
Buchmann, Arlette F.
dc.contributor.author
Blomeyer, Dorothea
dc.contributor.author
Jennen-Steinmetz, Christine
dc.contributor.author
Baumeister, Sarah
dc.contributor.author
Plichta, Michael M.
dc.contributor.author
Cattrell, Anna
dc.contributor.author
Schumann, Gunter
dc.contributor.author
Esser, Günther
dc.contributor.author
Schmidt, Martin
dc.contributor.author
Buitelaar, Jan
dc.contributor.author
Meyer-Lindenberg, Andreas
dc.contributor.author
Banaschewski, Tobias
dc.contributor.author
Brandeis, Daniel
dc.contributor.author
Laucht, Manfred
dc.date.accessioned
2019-10-10T16:16:16Z
dc.date.available
2017-10-06T03:24:13Z
dc.date.available
2017-11-27T12:20:54Z
dc.date.available
2019-10-10T16:16:16Z
dc.date.issued
2017-02
dc.identifier.issn
1749-5016
dc.identifier.issn
1749-5024
dc.identifier.other
10.1093/scan/nsw120
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191607
dc.identifier.doi
10.3929/ethz-b-000191607
dc.description.abstract
Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2–19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years). CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
fMRI
en_US
dc.subject
amygdala
en_US
dc.subject
conduct disorder
en_US
dc.subject
ventral striatum
en_US
dc.subject
childhood adversity
en_US
dc.title
Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2016-09-30
ethz.journal.title
Social Cognitive and Affective Neuroscience
ethz.journal.volume
12
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
Soc Cogn Affect Neurosci
ethz.pages.start
261
en_US
ethz.pages.end
272
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T03:24:15Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-27T12:20:57Z
ethz.rosetta.lastUpdated
2019-10-10T16:16:30Z
ethz.rosetta.versionExported
true
ethz.COinS
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