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dc.contributor.author
Kluin, Jolanda
dc.contributor.author
Talacua, Hanna
dc.contributor.author
Smits, Anthal I.P.M.
dc.contributor.author
Emmert, Maximilian Y.
dc.contributor.author
Brugmans, Marieke C.P.
dc.contributor.author
Fioretta, Emanuela S.
dc.contributor.author
Dijkman, Petra E.
dc.contributor.author
Söntjens, Serge H.M.
dc.contributor.author
Duijvelshoff, Renée
dc.contributor.author
Dekker, Sylvia
dc.contributor.author
Janssen-van den Broek, Marloes W.J.T.
dc.contributor.author
Lintas, Valentina
dc.contributor.author
Vink, Aryan
dc.contributor.author
Hoerstrup, Simon P.
dc.contributor.author
Janssen, Henk M.
dc.contributor.author
Dankers, Patricia Y.W.
dc.contributor.author
Baaijens, Frank P.T.
dc.contributor.author
Bouten, Carlijn V.C.
dc.date.accessioned
2017-11-20T14:32:44Z
dc.date.available
2017-10-06T03:27:35Z
dc.date.available
2017-11-20T14:32:44Z
dc.date.issued
2017-05
dc.identifier.other
10.1016/j.biomaterials.2017.02.007
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191618
dc.identifier.doi
10.3929/ethz-b-000191618
dc.description.abstract
The creation of a living heart valve is a much-wanted alternative for current valve prostheses that suffer from limited durability and thromboembolic complications. Current strategies to create such valves, however, require the use of cells for in vitro culture, or decellularized human- or animal-derived donor tissue for in situ engineering. Here, we propose and demonstrate proof-of-concept of in situ heart valve tissue engineering using a synthetic approach, in which a cell-free, slow degrading elastomeric valvular implant is populated by endogenous cells to form new valvular tissue inside the heart. We designed a fibrous valvular scaffold, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix. Orthotopic implantations as pulmonary valve in sheep demonstrated sustained functionality up to 12 months, while the implant was gradually replaced by a layered collagen and elastic matrix in pace with cell-driven polymer resorption. Our results offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Cardiovascular tissue engineering
en_US
dc.subject
Endogenous regeneration
en_US
dc.subject
Supramolecular chemistry
en_US
dc.subject
Biodegradable polymers
en_US
dc.subject
Pulmonary valve replacement
en_US
dc.subject
Regenerative biomaterials
en_US
dc.title
In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2017-02-08
ethz.journal.title
Biomaterials
ethz.journal.volume
125
en_US
ethz.pages.start
101
en_US
ethz.pages.end
117
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Kidlington
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T03:27:57Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-20T14:32:53Z
ethz.rosetta.lastUpdated
2018-08-03T02:43:42Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=In%20situ%20heart%20valve%20tissue%20engineering%20using%20a%20bioresorbable%20elastomeric%20implant%20-%20From%20material%20design%20to%2012%20months%20follow-up%20in%2&rft.jtitle=Biomaterials&rft.date=2017-05&rft.volume=125&rft.spage=101&rft.epage=117&rft.au=Kluin,%20Jolanda&Talacua,%20Hanna&Smits,%20Anthal%20I.P.M.&Emmert,%20Maximilian%20Y.&Brugmans,%20Marieke%20C.P.&rft.genre=article&
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