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dc.contributor.author
Sommer, Christian
dc.contributor.author
Garbusow, Maria
dc.contributor.author
Juenger, Elisabeth
dc.contributor.author
Pooseh, Shakoor
dc.contributor.author
Bernhardt, Nadine
dc.contributor.author
Birkenstock, J.
dc.contributor.author
Schad, Daniel J.
dc.contributor.author
Jabs, B.
dc.contributor.author
Gloeckler, T.
dc.contributor.author
Huys, Quentin J.M.
dc.contributor.author
Heinz, A.
dc.contributor.author
Smolka, M.N.
dc.contributor.author
Zimmermann, U.S.
dc.date.accessioned
2017-11-30T11:53:52Z
dc.date.available
2017-10-06T03:33:59Z
dc.date.available
2017-11-30T11:53:52Z
dc.date.issued
2017-08-01
dc.identifier.issn
2158-3188
dc.identifier.other
10.1038/tp.2017.158
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191703
dc.identifier.doi
10.3929/ethz-b-000191703
dc.description.abstract
Alcohol-related cues acquire incentive salience through Pavlovian conditioning and then can markedly affect instrumental behavior of alcohol-dependent patients to promote relapse. However, it is unclear whether similar effects occur with alcohol-unrelated cues. We tested 116 early-abstinent alcohol-dependent patients and 91 healthy controls who completed a delay discounting task to assess choice impulsivity, and a Pavlovian-to-instrumental transfer (PIT) paradigm employing both alcohol-unrelated and alcohol-related stimuli. To modify instrumental choice behavior, we tiled the background of the computer screen either with conditioned stimuli (CS) previously generated by pairing abstract pictures with pictures indicating monetary gains or losses, or with pictures displaying alcohol or water beverages. CS paired to money gains and losses affected instrumental choices differently. This PIT effect was significantly more pronounced in patients compared to controls, and the group difference was mainly driven by highly impulsive patients. The PIT effect was particularly strong in trials in which the instrumental stimulus required inhibition of instrumental response behavior and the background CS was associated to monetary gains. Under that condition, patients performed inappropriate approach behavior, contrary to their previously formed behavioral intention. Surprisingly, the effect of alcohol and water pictures as background stimuli resembled that of aversive and appetitive CS, respectively. These findings suggest that positively valenced background CS can provoke dysfunctional instrumental approach behavior in impulsive alcohol-dependent patients. Consequently, in real life they might be easily seduced by environmental cues to engage in actions thwarting their long-term goals. Such behaviors may include, but are not limited to, approaching alcohol.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Addiction
en_US
dc.subject
Human behaviour
en_US
dc.title
Strong seduction: impulsivity and the impact of contextual cues on instrumental behavior in alcohol dependence
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
Translational Psychiatry
ethz.journal.volume
7
en_US
ethz.journal.abbreviated
Transl Psychiatr
ethz.pages.start
e1183
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.date.deposited
2017-10-06T03:34:17Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-30T11:53:59Z
ethz.rosetta.lastUpdated
2018-11-06T04:34:57Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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