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dc.contributor.author
Grossman, Nir
dc.contributor.author
Bono, David
dc.contributor.author
Dedic, Nina
dc.contributor.author
Kodandaramaiah, Suhasa B.
dc.contributor.author
Rudenko, Andrii
dc.contributor.author
Suk, Ho-Jun
dc.contributor.author
Cassara, Antonio M.
dc.contributor.author
Neufeld, Esra
dc.contributor.author
Kuster, Niels
dc.contributor.author
Tsai, Li-Huei
dc.contributor.author
Pascual-Leone, Alvaro
dc.contributor.author
Boyden, Edward S.
dc.date.accessioned
2017-11-14T14:02:40Z
dc.date.available
2017-10-06T03:38:14Z
dc.date.available
2017-11-14T14:02:40Z
dc.date.issued
2017-06-01
dc.identifier.other
10.1016/j.cell.2017.05.024
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191791
dc.identifier.doi
10.3929/ethz-b-000191791
dc.description.abstract
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Cell
ethz.journal.volume
169
en_US
ethz.journal.issue
6
en_US
ethz.pages.start
1029
en_US
ethz.pages.end
1041.e16
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
s.l.
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T03:38:15Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-14T14:02:54Z
ethz.rosetta.lastUpdated
2019-02-02T13:21:59Z
ethz.rosetta.versionExported
true
ethz.COinS
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