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dc.contributor.author
Bedarf, Janis R.
dc.contributor.author
Hildebrand, Falk
dc.contributor.author
Coelho, Luis P.
dc.contributor.author
Sunagawa, Shinichi
dc.contributor.author
Bahram, Mohammad
dc.contributor.author
Goeser, Felix
dc.contributor.author
Bork, Peer
dc.contributor.author
Wüllner, Ullrich
dc.date.accessioned
2018-03-16T09:05:29Z
dc.date.available
2017-10-06T03:42:48Z
dc.date.available
2017-10-27T07:04:05Z
dc.date.available
2018-03-16T09:05:29Z
dc.date.issued
2017-04-28
dc.identifier.issn
1756-994X
dc.identifier.other
10.1186/s13073-017-0428-y
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191838
dc.identifier.doi
10.3929/ethz-b-000191838
dc.description.abstract
Background Parkinson’s disease (PD) presently is conceptualized as a protein aggregation disease in which pathology involves both the enteric and the central nervous system, possibly spreading from one to another via the vagus nerves. As gastrointestinal dysfunction often precedes or parallels motor symptoms, the enteric system with its vast diversity of microorganisms may be involved in PD pathogenesis. Alterations in the enteric microbial taxonomic level of L-DOPA-naïve PD patients might also serve as a biomarker. Methods We performed metagenomic shotgun analyses and compared the fecal microbiomes of 31 early stage, L-DOPA-naïve PD patients to 28 age-matched controls. Results We found increased Verrucomicrobiaceae (Akkermansia muciniphila) and unclassified Firmicutes, whereas Prevotellaceae (Prevotella copri) and Erysipelotrichaceae (Eubacterium biforme) were markedly lowered in PD samples. The observed differences could reliably separate PD from control with a ROC-AUC of 0.84. Functional analyses of the metagenomes revealed differences in microbiota metabolism in PD involving the ẞ-glucuronate and tryptophan metabolism. While the abundances of prophages and plasmids did not differ between PD and controls, total virus abundance was decreased in PD participants. Based on our analyses, the intake of either a MAO inhibitor, amantadine, or a dopamine agonist (which in summary relates to 90% of PD patients) had no overall influence on taxa abundance or microbial functions. Conclusions Our data revealed differences of colonic microbiota and of microbiota metabolism between PD patients and controls at an unprecedented detail not achievable through 16S sequencing. The findings point to a yet unappreciated aspect of PD, possibly involving the intestinal barrier function and immune function in PD patients. The influence of the parkinsonian medication should be further investigated in the future in larger cohorts.
en_US
dc.language.iso
en
en_US
dc.publisher
Biomed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Parkinson
en_US
dc.subject
Gut-brain axis
en_US
dc.subject
Enteric nervous system
en_US
dc.subject
Viruses
en_US
dc.subject
Microbiome
en_US
dc.subject
Archaea
en_US
dc.subject
Bacteria
en_US
dc.title
Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naive Parkinson's disease patients
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-04-28
ethz.journal.title
Genome Medicine
ethz.journal.volume
9
en_US
ethz.journal.abbreviated
Genome Med
ethz.pages.start
39
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::09583 - Sunagawa, Shinichi / Sunagawa, Shinichi
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::09583 - Sunagawa, Shinichi / Sunagawa, Shinichi
en_US
ethz.relation.isSupplementedBy
10.3929/ethz-b-000191807
ethz.date.deposited
2017-10-06T03:42:52Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-10-27T07:04:07Z
ethz.rosetta.lastUpdated
2018-11-06T15:58:52Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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