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dc.contributor.author
Noguchi, Shuhei
dc.contributor.author
Detmar, Michael
dc.contributor.author
Klein, Sarah
dc.contributor.author
et al.
dc.date.accessioned
2017-12-13T16:04:13Z
dc.date.available
2017-10-06T03:51:56Z
dc.date.available
2017-12-13T16:04:13Z
dc.date.issued
2017
dc.identifier.issn
2052-4463
dc.identifier.other
10.1038/sdata.2017.112
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191913
dc.identifier.doi
10.3929/ethz-b-000191913
dc.description.abstract
In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Data Descriptor: FANTOM5 CAGE profiles of human and mouse samples
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-08-29
ethz.journal.title
Scientific Data
ethz.journal.volume
4
en_US
ethz.journal.abbreviated
Sci Data
ethz.pages.start
170112
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T03:52:10Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-12-13T16:04:17Z
ethz.rosetta.lastUpdated
2017-12-13T16:04:17Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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