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dc.contributor.author
Azim, Kasum
dc.contributor.author
Angonin, Diane
dc.contributor.author
Marcy, Guillaume
dc.contributor.author
Pieropan, Francesca
dc.contributor.author
Rivera, Andrea
dc.contributor.author
Donega, Vanessa
dc.contributor.author
Cantù, Claudio
dc.contributor.author
Williams, Gareth
dc.contributor.author
Berninger, Benedikt
dc.contributor.author
Butt, Arthur M.
dc.contributor.author
Raineteau, Olivier
dc.date.accessioned
2017-12-05T12:01:27Z
dc.date.available
2017-10-06T04:14:59Z
dc.date.available
2017-10-10T13:29:26Z
dc.date.available
2017-10-10T13:31:24Z
dc.date.available
2017-12-05T12:00:23Z
dc.date.available
2017-12-05T12:01:27Z
dc.date.issued
2017-03
dc.identifier.issn
1544-9173
dc.identifier.issn
1545-7885
dc.identifier.other
10.1371/journal.pbio.2000698
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/191995
dc.identifier.doi
10.3929/ethz-b-000191995
dc.description.abstract
Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages. We identified multiple signaling pathways that trigger distinct downstream transcriptional networks to regulate the diversity of neural cells originating from the SVZ. Next, we used a novel in silico genomic analysis, searchable platform-independent expression database/connectivity map (SPIED/CMAP), to generate a catalogue of small molecules that can be used to manipulate SVZ microdomain-specific lineages. Finally, we demonstrate that compounds identified in this analysis promote the generation of specific cell lineages from NSCs in vivo, during postnatal life and adulthood, as well as in regenerative contexts. This study unravels new strategies for using small bioactive molecules to direct germinal activity in the SVZ, which has therapeutic potential in neurodegenerative diseases.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-03-28
ethz.journal.title
PLoS Biology
ethz.journal.volume
15
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
PLoS biol.
ethz.pages.start
e2000698
en_US
ethz.size
27 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
Lawrence, KS
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-10-06T04:15:08Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-10-10T13:29:32Z
ethz.rosetta.lastUpdated
2021-02-14T21:06:34Z
ethz.rosetta.versionExported
true
ethz.COinS
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