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dc.contributor.author
Siwowska, Klaudia
dc.contributor.author
Schmid, Raffaella M.
dc.contributor.author
Cohrs, Susan
dc.contributor.author
Schibli, Roger
dc.contributor.author
Müller, Cristina
dc.date.accessioned
2019-08-09T07:37:10Z
dc.date.available
2017-10-06T05:14:54Z
dc.date.available
2017-11-28T12:56:19Z
dc.date.available
2018-01-11T13:16:15Z
dc.date.available
2019-08-09T07:37:10Z
dc.date.issued
2017-09
dc.identifier.other
10.3390/ph10030072
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/192547
dc.identifier.doi
10.3929/ethz-b-000192547
dc.description.abstract
The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes. The cervical KB tumor cells have evolved as the standard model for preclinical investigations of folate-based (radio) conjugates. In this study, a panel of FR-expressing human cancer cell lines—including cervical (HeLa, KB, KB-V1), ovarian (IGROV-1, SKOV-3, SKOV-3.ip), choriocarcinoma (JAR, BeWo) and endometrial (EFE-184) tumor cells—was investigated in vitro and for their ability to grow as xenografts in mice. FR-expression levels were compared in vitro and in vivo and the cell lines were characterized by determination of the sensitivity towards commonly-used chemotherapeutics and the expression of two additional, relevant tumor markers, HER2 and L1-CAM. It was found that, besides KB cells, its multiresistant KB-V1 subclone as well as the ovarian cancer cell lines, IGROV-1 and SKOV-3.ip, could be used as potentially more relevant preclinical models. They would allow addressing specific questions such as the therapeutic efficacy of FR-targeting agents in tumor (mouse) models of multi-resistance and in mouse models of metastases formation.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
folate receptor
en_US
dc.subject
folic acid
en_US
dc.subject
Ovarian cancer
en_US
dc.subject
cervical cancer
en_US
dc.subject
Endometrial cancer
en_US
dc.subject
choriocarcinoma
en_US
dc.subject
KB
en_US
dc.subject
KB-V1
en_US
dc.subject
IGROV-1
en_US
dc.subject
SKOV-3
en_US
dc.subject
SKOV-3.ip
en_US
dc.title
Folate receptor-positive gynecological cancer cells: in vitro and in vivo characterization
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-08-15
ethz.journal.title
Pharmaceuticals
ethz.journal.volume
10
en_US
ethz.journal.issue
3
en_US
ethz.pages.start
72
en_US
ethz.size
17 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Development of New Folate-Based RadioImaging Agents and RadioTherapeutics
en_US
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.grant.agreementno
156803
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
ethz.date.deposited
2017-10-06T05:14:56Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-11-28T12:56:24Z
ethz.rosetta.lastUpdated
2019-08-09T07:37:21Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Folate%20receptor-positive%20gynecological%20cancer%20cells:%20in%20vitro%20and%20in%20vivo%20characterization&rft.jtitle=Pharmaceuticals&rft.date=2017-09&rft.volume=10&rft.issue=3&rft.spage=72&rft.au=Siwowska,%20Klaudia&Schmid,%20Raffaella%20M.&Cohrs,%20Susan&Schibli,%20Roger&M%C3%BCller,%20Cristina&rft.genre=article&
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